| Disease Term | Human Homologs | Mouse Homologs | Mouse Models | Homology Source | |||
  | adrenoleukodystrophy | ABCD1* | Abcd1* | 9 models | Alliance of Genome Resources | ||
| adult-onset autosomal dominant demyelinating leukodystrophy | LMNB1* | Lmnb1* | 1 model | Alliance of Genome Resources | |||
| Alexander disease | GFAP* | Gfap* | 4 models | Alliance of Genome Resources | |||
| CADASIL 1 | NOTCH3* | Notch3* | 6 models | Alliance of Genome Resources | |||
| Canavan disease | ASPA* | Aspa* | 4 models | Alliance of Genome Resources | |||
| hypomyelinating leukodystrophy 2 | GJC2* | Gjc2* | 3 models | Alliance of Genome Resources | |||
| hypomyelinating leukodystrophy 6 | TUBB4A* | Tubb4a* | 3 models | Alliance of Genome Resources | |||
| leukoencephalopathy with vanishing white matter | EIF2B5* | Eif2b5* | 7 models | Alliance of Genome Resources | |||
| megalencephalic leukoencephalopathy with subcortical cysts 1 | MLC1* | Mlc1* | 1 model | Alliance of Genome Resources | |||
| normal pressure hydrocephalus | CFAP43* | Cfap43* | 1 model | Alliance of Genome Resources | |||
| Pelizaeus-Merzbacher disease | PLP1* | Plp1* | 8 models | Alliance of Genome Resources | |||
| | Canavan disease | SOD2 | Sod2* | 1 model | Alliance of Genome Resources | ||
| hydrocephalus | SOX3 | Sox3* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | ADD1 | Add1* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | AK7 | Ak7* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | AK8 | Ak8* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | CCDC39 | Ccdc39* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | CCDC85C | Ccdc85c* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | CELSR2 | Celsr2* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | DPCD | Dpcd* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | E2F5 | E2f5* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | HYDIN | Hydin* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | KIF27 | Kif27* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | MBOAT7 | Mboat7* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | NME5 | Nme5* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | NME7 | Nme7* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | POMK | Pomk* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | STK36 | Stk36* | 1 model | Alliance of Genome Resources | |||
| hydrocephalus | ULK4 | Ulk4* | 1 model | Alliance of Genome Resources | |||
| leukodystrophy | CLCN2 | Clcn2* | 1 model | Alliance of Genome Resources | |||
| leukoencephalopathy with vanishing white matter | EIF2B4 | Eif2b4* | 4 models | Alliance of Genome Resources | |||
| megalencephalic leukoencephalopathy with subcortical cysts | HEPACAM | Hepacam* | 1 model | Alliance of Genome Resources | |||
| neuroaxonal dystrophy | BORCS7 | Borcs7* | 1 model | Alliance of Genome Resources | |||
| normal pressure hydrocephalus | AK9 | Ak9* | 1 model | Alliance of Genome Resources | |||
| normal pressure hydrocephalus | p23-ST1* | 1 model | |||||
| normal pressure hydrocephalus | CWH43 | Cwh43* | 3 models | Alliance of Genome Resources | |||
| obstructive hydrocephalus | MYO9A | Myo9a* | 1 model | Alliance of Genome Resources | |||
| | adult-onset leukoencephalopathy with axonal spheroids and pigmented glia | CSF1R* | Csf1r | Alliance of Genome Resources | |||
| CADASIL | HTRA1* | Htra1 | Alliance of Genome Resources | ||||
| CADASIL 2 | HTRA1* | Htra1 | Alliance of Genome Resources | ||||
| hydrocephalus | CCDC88C* | Ccdc88c | Alliance of Genome Resources | ||||
| hydrocephalus | L1CAM* | L1cam | Alliance of Genome Resources | ||||
| hydrocephalus | MPDZ* | Mpdz | Alliance of Genome Resources | ||||
| hydrocephalus | SMARCC1* | Smarcc1 | Alliance of Genome Resources | ||||
| hydrocephalus | TRIM71* | Trim71 | Alliance of Genome Resources | ||||
| hydrocephalus | WDR81* | Wdr81 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 10 | PYCR2* | Pycr2 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 11 | POLR1C* | Polr1c | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 12 | VPS11* | Vps11 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 13 | HIKESHI* | Hikeshi | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 14 | UFM1* | Ufm1 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 15 | EPRS1* | Eprs1 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 16 | TMEM106B* | Tmem106b | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 17 | AIMP2* | Aimp2 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 18 | DEGS1* | Degs1, Degs1l | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 19 | TMEM63A* | Tmem63a | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 20 | CNP* | Cnp | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 21 | POLR3K* | Polr3k | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 22 | CLDN11* | Cldn11 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 23 | RNF220* | Rnf220 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 24 | ATP11A* | Atp11a | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 25 | TMEM163* | Tmem163 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 26 | SLC35B2* | Slc35b2 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 3 | AIMP1* | Aimp1 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 4 | HSPD1* | Hspd1 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 5 | HYCC1* | Hycc1 | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 7 | POLR3A* | Polr3a | 2 "NOT" models | Alliance of Genome Resources | |||
| hypomyelinating leukodystrophy 8 | POLR3B* | Polr3b | Alliance of Genome Resources | ||||
| hypomyelinating leukodystrophy 9 | RARS1* | Rars1 | Alliance of Genome Resources | ||||
| leukodystrophy | AARS1* | Aars1 | Alliance of Genome Resources | ||||
| leukoencephalopathy with vanishing white matter | EIF2B2* | Eif2b2 | Alliance of Genome Resources | ||||
| leukoencephalopathy with vanishing white matter 1 | EIF2B1* | Eif2b1 | Alliance of Genome Resources | ||||
| leukoencephalopathy with vanishing white matter 2 | EIF2B2* | Eif2b2 | Alliance of Genome Resources | ||||
| leukoencephalopathy with vanishing white matter 3 | EIF2B3* | Eif2b3 | Alliance of Genome Resources | ||||
| leukoencephalopathy with vanishing white matter 4 | EIF2B4* | Eif2b4 | Alliance of Genome Resources | ||||
| leukoencephalopathy with vanishing white matter 5 | EIF2B5* | Eif2b5 | Alliance of Genome Resources | ||||
| megalencephalic leukoencephalopathy with subcortical cysts | GPRC5B* | Gprc5b | Alliance of Genome Resources | ||||
| megalencephalic leukoencephalopathy with subcortical cysts | AQP4* | Aqp4 | Alliance of Genome Resources | ||||
| megalencephalic leukoencephalopathy with subcortical cysts 2A | HEPACAM* | Hepacam | Alliance of Genome Resources | ||||
| megalencephalic leukoencephalopathy with subcortical cysts 2B | HEPACAM* | Hepacam | Alliance of Genome Resources | ||||
| neuroaxonal dystrophy | NAGA* | Naga | Alliance of Genome Resources | ||||
| neuroaxonal dystrophy | PLA2G6* | Pla2g6 | Alliance of Genome Resources | ||||
| progressive leukoencephalopathy with ovarian failure | AARS2* | Aars2 | Alliance of Genome Resources | ||||
| RNASET2-deficient cystic leukoencephalopathy | RNASET2* | Rnaset2a, Rnaset2b | Alliance of Genome Resources | ||||
Excel File
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Transgenes and other genome features developed in mice to model this disease.
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| Disease Term | Transgenes and Other Genome Features | Mouse Models | |
| adult-onset autosomal dominant demyelinating leukodystrophy | Tg(Plp1-LMNB1)1108Qsp | 1 model | |
| adult-onset autosomal dominant demyelinating leukodystrophy | Tg(Plp1-Lmnb1)#Yfu | 1 model | |
| adult-onset autosomal dominant demyelinating leukodystrophy | Tg(Lmnb1)1Yfu | 1 model | |
| Alexander disease | Tg(GFAP)10Mes | 3 models | |
| Alexander disease | Tg(GFAP)7Mes | 1 model | |
| Alexander disease | Tg(Gfap-GFAP*R239H)60TMIke | 1 model | |
| CADASIL 1 | Tg(Notch3*R169C)88Bbb | 1 model | |
| hydrocephalus | Tg(Sox3)1Pqt | 1 model | |
| leukoencephalopathy with vanishing white matter | Tg(Plp1-Eif2ak3*)18Pop | 1 model | |
| Pelizaeus-Merzbacher disease | Tg(Plp)66Kan | 2 models | |
| Pelizaeus-Merzbacher disease | Tg(Plp)72Kan | 1 model | |
| Pelizaeus-Merzbacher disease | Dp(XTceal3-Plp1)1Gmh | 1 model | |