Prkci Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8352277
Gene symbol:	Prkci
Gene name:	protein kinase C, iota

Antibody:	Anti-PKC zeta (sc-216; C-20)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

S4C WT row 1 ©

S4C WT row 2 ©

S4C WT row 3 ©

Specimen S4C WT: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: green - Prkci; magenta - Ctnnb1 (assay MGI:8351284); cyan - Golga2 (assay MGI:8352276).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	Present	Regionally restricted	S4C WT row 1 , S4C WT row 3 , S4C WT row 2	Prkci is an apical polarity marker.

Specimen S4C Lats1/2^PanKO: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: green - Prkci; magenta - Ctnnb1 (assay MGI:8351284); cyan - Golga2 (assay MGI:8352276).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	Present	Regionally restricted	S4C Lats1/2^PanKO row 3 , S4C Lats1/2^PanKO row 2 , S4C Lats1/2^PanKO row 1	A distinct displacement of apical surfaces was noted in the mutant.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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