Sox9 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8351676
Gene symbol:	Sox9
Gene name:	SRY (sex determining region Y)-box 9

Antibody:	Anti-Sox9 (AB5535)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

S2E WT ©

Specimen S2E WT: embryonic day 12.5 (more

)
Note: Controls were either wild type or heterozygous littermates.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S2E WT

S2E Lats1/2/Yap1^PanKOTaz^Het ©

Specimen S2E Lats1/2/Yap1^PanKOTaz^Het: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0, Wwtr1^tm1.1Eno/Wwtr1⁺, Yap1^tm1.1Eno/Yap1^tm1.1Eno (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Weak		S2E Lats1/2/Yap1^PanKOTaz^Het	Expression was not rescued in the Lats1/2/Yap1<PanKO>Taz<Het> pancreas.

S2E Lats1/2^PanKO ©

Specimen S2E Lats1/2^PanKO: embryonic day 13.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: pancreas	Weak		S2E Lats1/2^PanKO

S3C WT upper ©

Specimen S3C WT: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates.

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	Present		S3C WT upper

S3C Lats1/2^PanKO upper ©

Specimen S3C Lats1/2^PanKO: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium epithelium	Weak		S3C Lats1/2^PanKO upper

S3D WT lower ©

Specimen S3D WT: embryonic day 13.5 (more

)
Note: Controls were either wild type or heterozygous littermates.

Structure	Level	Pattern	Image	Note
TS21: pancreas epithelium	Present		S3D WT lower

Specimen S3D Lats1/2^PanKO: embryonic day 13.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: pancreas epithelium	Weak		S3D Lats1/2^PanKO lower

S10B WT ©

Specimen S10B WT: embryonic day 15.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Triple labeled: magenta - Sox9; red - Ctnnb1 (assay MGI:8351284); green - Hif1a (assay MGI:8352258).

Structure	Level	Pattern	Image	Note
TS23: pancreas	Present		S10B WT

Specimen S10B Lats1/2^PanKO: embryonic day 15.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Triple labeled: magenta - Sox9; red - Ctnnb1 (assay MGI:8351284); green - Hif1a (assay MGI:8352258).

Structure	Level	Pattern	Image	Note
TS23: pancreas	Weak		S10B Lats1/2^PanKO

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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