Vnn1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8351300
Gene symbol:	Vnn1
Gene name:	vanin 1

Antibody:	Anti-VNN1 (21745-1-AP)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

3F ©

Specimen 3F: embryonic day 11.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: green - Vnn1; red - Ctnnb1 (assay MGI:8351284).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Weak		3F

3G ©

Specimen 3G: embryonic day 11.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: green - Vnn1; red - Ctnnb1 (assay MGI:8351284).

Structure	Level	Pattern	Image	Note
TS19: pancreas primordium	Present		3G	Significantly increased VNN1 protein levels were observed in Lats1/2PanKO pancreas.

S7C WT ©

Specimen S7C WT: embryonic day 13.5 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: green - Vnn1; red - Cdh1 (assay MGI:8346384).

Structure	Level	Pattern	Image	Note
TS21: pancreas	Weak		S7C WT

Specimen S7C Lats1/2^PanKO: embryonic day 13.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: green - Vnn1; red - Cdh1 (assay MGI:8346384).

Structure	Level	Pattern	Image	Note
TS21: pancreas	Present		S7C Lats1/2^PanKO	Significantly increased VNN1 protein levels were noted in Lats1/2<PanKO> pancreas.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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