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Gene Expression Data
Assay Details
Assay
Reference: J:341393 Cheffer A, et al., DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons. Cereb Cortex. 2023 Sep 26;33(19):10272-10285
Assay type: RT-PCR
MGI Accession ID: MGI:8326835
Gene symbol: Dot1l
Gene name: DOT1 like histone lysine methyltransferase
Probe: Dot1l-pF, Dot1l-pR
Assay notes: Quantitative RT-PCR. Relative expression was normalized to Gapdh.
Results
Image: S1A ©

 Sample Information Bands Other Sample Information
Lane AgeStructure Size Not Specified Amount Genetic BackgroundMutant Allele(s)Sex Note
Dot1l-DT Foxg1-cre;Dot1l control E14.5 TS22: telencephalon Present 1 µg; total RNA involves: 129P2/OlaHsd * C57BL/6N Dot1ltm1c(KOMP)Wtsi/?Not Specified Dorsal telencephalon. Littermate controls were either Foxg1<+/+>:Dot1l<flox/+> or Foxg1<+/+>:Dot1l<flox/flox>.
Dot1l-DT Foxg1-cre;Dot1l cKO E14.5 TS22: telencephalon Absent (a) 1 µg; total RNA involves: 129P2/OlaHsd * C57BL/6N Dot1ltm1c(KOMP)Wtsi/Dot1ltm1c(KOMP)Wtsi, Foxg1tm1(cre)Skm/Foxg1+Not Specified Conditional mutant. Dorsal telencephalon.
Dot1l-VT Foxg1-cre;Dot1l control E14.5 TS22: telencephalon Present 1 µg; total RNA involves: 129P2/OlaHsd * C57BL/6N Dot1ltm1c(KOMP)Wtsi/?Not Specified Ventral telencephalon. Littermate controls were either Foxg1<+/+>:Dot1l<flox/+> or Foxg1<+/+>:Dot1l<flox/flox>.
Dot1l-VT Foxg1-cre;Dot1l cKO E14.5 TS22: telencephalon Absent (a) 1 µg; total RNA involves: 129P2/OlaHsd * C57BL/6N Dot1ltm1c(KOMP)Wtsi/Dot1ltm1c(KOMP)Wtsi, Foxg1tm1(cre)Skm/Foxg1+Not Specified Conditional mutant. Ventral telencephalon.
Notes:
(a) Foxg1-Cre-driver activity resulted in the loss of Dot1l transcription in both dorsal and ventral telencephalon.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/15/2026
MGI 6.29 		The Jackson Laboratory