About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:364871 Casado-Navarro R, et al., Expression atlas of Dmrt genes across sex and development in the mouse brain: functional insights from the olfactory system. Biol Sex Differ. 2026;17(1):44
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8310124
Gene symbol: Dmrta2
Gene name: doublesex and mab-3 related transcription factor like family A2
Antibody: anti-Dmrt5
Detection system: Secondary antibody
Results
Specimen 1Q: embryonic day 14.5 (more )
Note: Double labeled: blue - Dmrta2; red - Dmrta1 (assay MGI:8310121).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 1Q Expression is seen in the ventral midbrain; the region of expression does not overlap with Dmrt4 expression.

Specimen 4a': embryonic day 18.5 (more )
Note: Coronal view. Double labeled: green - Dmrta2; magenta - Slc17a6 (assay MGI:8314911).
Structure Level Pattern Image Note
TS26: hypothalamus Present 4a' Expression is seen in the lateral hypothalamus; the expression domain is largely glutamatergic (colocalizes with the domain of Vglut2 expression).

Specimen 4b': embryonic day 18.5 (more )
Note: Coronal view. Double labeled: green - Dmrta2; magenta - Slc17a6 (assay MGI:8314911).
Structure Level Pattern Image Note
TS26: ventral tegmental area Present 4b' The expression domain is largely glutamatergic (colocalizes with the domain of Vglut2 expression).

Specimen 5B: embryonic day 18.5 (more )
Note: Coronal view. Subjected to the iDISCO+ protocol. Double labeled: red - Dmrta2; green - Dmrt3 (assay MGI:8315019).
Structure Level Pattern Image Note
TS26: dentate gyrus Present Single cells 5Bb , 5B right The area of expression overlaps with that of Dmrt3.

Specimen 5C/D: postnatal day 7 (more )
Note: Multi-labeled: green - Dmrta2; magenta - Reln (assay MGI:8315024); red - Sox2 (assay MGI:8315023); blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: hippocampal formation Present 5D , 5C
TS28: dentate gyrus hilus neural progenitor cell Present Single cells 5D , 5C , 5Di Expression co-localizes with Sox2 expression.
TS28: dentate gyrus hilus neural stem cell Present Single cells 5D , 5C , 5Di Expression co-localizes with Sox2 expression.
TS28: hippocampal formation Cajal-Retzius cell Present Single cells 5Dii , 5D , 5C Expression co-localizes with Reelin expression.

Specimen 5E/F: postnatal day 25 (more )
Note: Multi-labeled: green - Dmrta2; magenta - Reln (assay MGI:8315024); red - Sox2 (assay MGI:8315023); blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: hippocampal formation Present 5F , 5E
TS28: dentate gyrus subgranular zone neural progenitor cell Present Single cells 5E , 5Fiii , 5F Expression co-localizes with Sox2 expression.
TS28: dentate gyrus subgranular zone neural stem cell Present Single cells 5E , 5Fiii , 5F Expression co-localizes with Sox2 expression.
TS28: hippocampal formation Cajal-Retzius cell Present Single cells 5Fiv , 5E , 5F Expression co-localizes with Reln expression.

Specimen 6C: embryonic day 14.5 (more )
Note: Multi-labeled: green - Dmrta2; magenta - Omp (assay MGI:8315422); red - Sox2 (assay MGI:8315023); yellow - Tubb3 (assay MGI:8315421).
Structure Cell Type Level Pattern Image Note
TS22: olfactory epithelium Present 6C , 6Ci Expression is seen in the apical and basal layer.
TS22: olfactory epithelium neural stem cell Present Single cells 6C , 6Ci Expression is seen in olfactory neural stem cells as well as cells likely to be differentiating intermediate progenitors.
TS22: olfactory epithelium olfactory epithelial supporting cell Present Single cells 6Ci , 6C Expression is seen in sustentacular cells.
TS22: olfactory epithelium olfactory receptor cell Present Single cells 6C , 6Ciii , 6Cii Expression is seen in immature (TuJ1+) and mature (OMP+) sensory neurons.
TS22: vomeronasal organ Present Regionally restricted 6Civ , 6C Areas of expression do not overlap with that of Sox2 expression.
TS22: vomeronasal organ epithelium sustentacular cell Absent 6Civ , 6C No expression is seen in sustentacular cells.
TS22: vomeronasal organ sensory epithelium vomeronasal sensory neuron Present 6Cv , 6C , 6Cvi Expression is seen in immature (TuJ1+) and mature (OMP+) sensory neurons.
TS22: vomeronasal organ non-sensory epithelium Present 6C , 6Cv , 6Cvi Expression is seen in TuJ1+ and OMP+ cells.

Specimen 6E: postnatal day 71 (more )
Note: Double labeled: green - Dmrta2; blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: olfactory epithelium olfactory epithelial supporting cell Strong 6e' , 6E Robust staining is located in the sustentacular layer.
TS28: olfactory epithelium basal cell of olfactory epithelium Present Single cells 6E , 6e' Expression is seen in a few cells in the basal layer where olfactory neural stem cells are located.
TS28: olfactory epithelium Present 6E , 6e'' Expression is seen in the nasal turbinates, including a prominent concentration of expressing cells in the "cul-de-sacs" that contain non-canonical olfactory sensory neurons.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/06/2026
MGI 6.29
The Jackson Laboratory