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Gene Expression Data
Assay Details
Assay
Reference: J:364871 Casado-Navarro R, et al., Expression atlas of Dmrt genes across sex and development in the mouse brain: functional insights from the olfactory system. Biol Sex Differ. 2026;17(1):44
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8315023
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2 (AF2018)
Detection system: Secondary antibody
Results
Specimen 5D: postnatal day 7 (more )
Note: Multi-labeled: red - Sox2; green - Dmrta2 (assay MGI:8310124); magenta - Reln (assay MGI:8315024); blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: dentate gyrus hilus neural progenitor cell Present Single cells 5Di , 5D Expression co-localizes with Dmrt5 expression.
TS28: dentate gyrus hilus neural stem cell Present Single cells 5Di , 5D Expression co-localizes with Dmrt5 expression.

Specimen 5F: postnatal day 25 (more )
Note: Multi-labeled: red - Sox2; green - Dmrta2 (assay MGI:8310124); magenta - Reln (assay MGI:8315024); blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: dentate gyrus subgranular zone neural progenitor cell Present Single cells 5Fiii , 5F Expression co-localizes with Dmrt5 expression.
TS28: dentate gyrus subgranular zone neural stem cell Present Single cells 5Fiii , 5F Expression co-localizes with Dmrt5 expression.
TS28: dentate gyrus hilus Present Single cells 5Fiii , 5F Expressing cells are seen outside the subgranular zone; it is assumed they are astrocytes.

Specimen 6C: embryonic day 14.5 (more )
Note: Double labeled: red - Sox2; green - Dmrta2 (assay MGI:8310124).
Structure Cell Type Level Pattern Image Note
TS22: olfactory epithelium neural stem cell Present Single cells 6Ci Expression is seen in olfactory neural stem cells as well as cells likely to be differentiating intermediate progenitors.
TS22: olfactory epithelium olfactory epithelial supporting cell Present Single cells 6Ci Expression is seen in sustentacular cells.
TS22: vomeronasal organ neural stem cell Present 6Civ Areas of expression do not overlap with that of Dmrt5 expression.

Specimen 7D: embryonic day 14.5 (more )
Note: Wild type.
Structure Cell Type Level Pattern Image Note
TS22: olfactory epithelium neural progenitor cell Present Single cells 7D Expression is seen in the basal layer, in olfactory neural progenitor cells.
TS22: olfactory epithelium olfactory epithelial supporting cell Present Single cells 7D Expression is seen in the apical layer, in sustentacular cells.

Specimen 7D': embryonic day 14.5; Dmrta2tm1Ejbd/Dmrta2tm1Ejbd (more )
Structure Level Pattern Image Note
TS22: olfactory epithelium Present Widespread 7D' In mutants expressing cells are randomly distributed across the epithelium, indicating that the olfactory epithelium has lost its organized layer stratification.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/06/2026
MGI 6.29
The Jackson Laboratory