About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:339839 Ross JA, et al., Lem2 is essential for cardiac development by maintaining nuclear integrity. Cardiovasc Res. 2023 Sep 5;119(11):2074-2088
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8296611
Gene symbol: Actn2
Gene name: actinin alpha 2
Results
Specimen S1D Control: embryonic day 14.5 (more )
Note: Double labeled: red - Actn2; green - Lemd2 (assay MGI:8296608).
Structure Cell Type Level Pattern Image Note
TS22: heart cardiac muscle cell Present S1D Control , S1D Control Zoom Expression in cardiomyocytes.
Specimen S1D cKO: embryonic day 14.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Double labeled: red - Actn2; green - Lemd2 (assay MGI:8296608).
Structure Level Pattern Image Note
TS22: heart Present S1D cKO , S1D cKO Zoom p
Specimen S1I Control: embryonic day 16.5 (more )
Note: Double labeled: red - Actn2; green - Tagln (assay MGI:8296610).
Structure Level Pattern Image Note
TS24: heart Present S1I Control
Specimen S1I Control RV: embryonic day 16.5 (more )
Note: Double labeled: red - Actn2; green - Tagln (assay MGI:8296610).
Structure Level Pattern Image Note
TS24: heart right ventricle Present S1I Control RV
Specimen S1I Control LV: embryonic day 16.5 (more )
Note: Double labeled: red - Actn2; green - Tagln (assay MGI:8296610).
Structure Level Pattern Image Note
TS24: heart left ventricle Present S1I Control LV
Specimen S1I cKO: embryonic day 16.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Double labeled: red - Actn2; green - Tagln (assay MGI:8296610).
Structure Level Pattern Image Note
TS24: heart Present S1I cKO
Specimen S1I cKO RV: embryonic day 16.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Double labeled: red - Actn2; green - Tagln (assay MGI:8296610).
Structure Level Pattern Image Note
TS24: heart right ventricle Present S1I cKO RV
Specimen S1I cKO LV: embryonic day 16.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Double labeled: red - Actn2; green - Tagln (assay MGI:8296610).
Structure Level Pattern Image Note
TS24: heart left ventricle Present S1I cKO LV
Specimen 3A Control: embryonic day 14.5 (more )
Note: Double labeled: red - Actn2; green - Casp3 (assay MGI:8296619).
Structure Level Pattern Image Note
TS22: heart Present Scattered 3A Control
Specimen 3A cKO: embryonic day 14.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Double labeled: red - Actn2; green - Casp3 (assay MGI:8296619).
Structure Level Pattern Image Note
TS22: heart Present 3A cKO
Specimen 3C Control: embryonic day 14.5 (more )
Note: Double labeled: red - Actn2; green - H2ax (assay MGI:8296621).
Structure Level Pattern Image Note
TS22: heart Present 3C Control
Specimen 3C cKO: embryonic day 14.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Double labeled: red - Actn2; green - H2ax (assay MGI:8296621).
Structure Level Pattern Image Note
TS22: heart Present 3C cKO
Specimen 3E Control: embryonic day 14.5 (more )
Note: Double labeled: magenta - Actn2; green - DAPI.
Structure Level Pattern Image Note
TS22: heart Present 3E Control
Specimen 3E cKO: embryonic day 14.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Double labeled: magenta - Actn2; green - DAPI.
Structure Level Pattern Image Note
TS22: heart Present 3E cKO
Specimen 3G Control: embryonic day 14.5 (more )
Note: Double labeled: red - Actn2; green - EdU.
Structure Level Pattern Image Note
TS22: heart Present 3G Control
Specimen 3G cKO: embryonic day 14.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Double labeled: red - Actn2; green - EdU.
Structure Level Pattern Image Note
TS22: heart Present 3G cKO
Specimen S3F Control: postnatal day 0 (more )
Note: Double labeled: magenta - Actn2; green - Casp3 (assay MGI:8296619).
Structure Level Pattern Image Note
TS27: heart Present S3F Control
Specimen S3F cTnT cKO: postnatal day 0; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(Tnnt2-cre)5Blh/0 (more )
Note: Conditional mutant. Double labeled: magenta - Actn2; green - Casp3 (assay MGI:8296619).
Structure Level Pattern Image Note
TS27: heart Present S3F cTNT cKO
Specimen S3G Control: postnatal day 0 (more )
Note: Double labeled: magenta - Actn2; green - phospho-histone.
Structure Level Pattern Image Note
TS27: heart Present S3G Control
Specimen S3G cTnT cKO: postnatal day 0; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(Tnnt2-cre)5Blh/0 (more )
Note: Conditional mutant. Double labeled: magenta - Actn2; green - phospho-histone.
Structure Level Pattern Image Note
TS27: heart Present S3G cTNT cKO
Specimen 5B Longitudinal: postnatal week 8 (more )
Note: Double labeled: red - Actn2; green - Lemd2 (assay MGI:8296608).
Structure Level Pattern Image Note
TS28: heart Present 5B Longitudinal , 5B Longitudinal inset
Specimen 5B Transverse: postnatal week 8 (more )
Note: Double labeled: red - Actn2; green - Lemd2 (assay MGI:8296608).
Structure Level Pattern Image Note
TS28: heart Present 5B Transverse , 5B Transverse inset
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory