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Gene Expression Data
Assay Details
Assay
Reference: J:339839 Ross JA, et al., Lem2 is essential for cardiac development by maintaining nuclear integrity. Cardiovasc Res. 2023 Sep 5;119(11):2074-2088
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8296621
Gene symbol: H2ax
Gene name: H2A.X variant histone
Results
Specimen 3C Control: embryonic day 14.5 (more )
Note: Double labeled: green - H2ax; red - Actn2 (assay MGI:8296611).
Structure Level Pattern Image Note
TS22: heart Present Regionally restricted 3C Control
Specimen 3C cKO: embryonic day 14.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Double labeled: green - H2ax; red - Actn2 (assay MGI:8296611).
Structure Level Pattern Image Note
TS22: heart Present 3C cKO Increased levels of expression compared to control at E14.5.
Specimen LV Control: embryonic day 14.5 (more )
Note: Data presented in Supplementary Figure 3C.
Structure Level Pattern Image Note
TS22: heart left ventricle Present
Specimen LV cKO: embryonic day 14.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Data presented in Supplementary Figure 3C.
Structure Level Pattern Image Note
TS22: heart left ventricle Present Increased levels of expression compared to control at E14.5.
Specimen RV Control: embryonic day 14.5 (more )
Note: Data presented in Supplementary Figure 3C.
Structure Level Pattern Image Note
TS22: heart right ventricle Present
Specimen RV cKO: embryonic day 14.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Data presented in Supplementary Figure 3C.
Structure Level Pattern Image Note
TS22: heart right ventricle Present Increased levels of expression compared to control at E14.5.
Specimen IVS Control: embryonic day 14.5 (more )
Note: Data presented in Supplementary Figure 3C.
Structure Level Pattern Image Note
TS22: interventricular septum Present
Specimen IVS cKO: embryonic day 14.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Data presented in Supplementary Figure 3C.
Structure Level Pattern Image Note
TS22: interventricular septum Present Increased levels of expression compared to control at E14.5.
Specimen E13.5 Control: embryonic day 13.5 (more )
Note: Data presented in Supplementary Figure 3D.
Structure Level Pattern Image Note
TS21: heart Present
Specimen E13.5 cKO: embryonic day 13.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Data presented in Supplementary Figure 3D.
Structure Level Pattern Image Note
TS21: heart Present
Specimen E16.5 Control: embryonic day 16.5 (more )
Note: Data presented in Supplementary Figure 3D.
Structure Level Pattern Image Note
TS24: heart Present
Specimen E16.5 cKO: embryonic day 16.5; Lemd2tm1c(EUCOMM)Wtsi/Lemd2tm1c(EUCOMM)Wtsi, Tg(myl7.L-cre)1118Tmhn/0 (more )
Note: Conditional mutant. Data presented in Supplementary Figure 3D.
Structure Level Pattern Image Note
TS24: heart Present Increased levels of expression compared to control at E16.5.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
MGI 6.24 		The Jackson Laboratory