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Gene Expression Data
Assay Details
Assay
Reference: J:232175 Diaz-Horta O, et al., ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice. Proc Natl Acad Sci U S A. 2016 May 24;113(21):5993-8
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8291837
Gene symbol: Nefh
Gene name: neurofilament, heavy polypeptide
Results
Specimen 2D wildtype: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 2D wildtype Expression was detected in radial bundle fibers of spiral ganglion axons in the cochlea.
TS28: peripheral nerve fiber Present Regionally restricted 2D wildtype Expression was detected in radial bundle fibers of spiral ganglion axons in the cochlea.

Specimen 2D mutant: postnatal day 5; Ror1tm1Ymi/Ror1tm1Ymi (more )
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 2D mutant Defects in fasciculation of radial bundle fibers were observed in the mutant cochlea.
TS28: peripheral nerve fiber Present Regionally restricted 2D mutant Defects in fasciculation of radial bundle fibers were observed in the mutant cochlea.

Specimen 2F wildtype: postnatal day 5 (more )
Note: Triple labeled: cyan - Nefh; yellow - Prph (assay MGI:8291844); magenta - Phalloidin.
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 2F wildtype Merge + Actin , 2F wildtype NF Expression was detected in spiral ganglion peripheral axons in the base of the cochlea.
TS28: peripheral nerve fiber Present Regionally restricted 2F wildtype Merge + Actin , 2F wildtype NF Expression was detected in spiral ganglion peripheral axons in the base of the cochlea.

Specimen 2F mutant: postnatal day 5; Ror1tm1Ymi/Ror1tm1Ymi (more )
Note: Triple labeled: cyan - Nefh; yellow - Prph (assay MGI:8291844); magenta - Phalloidin.
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted 2F mutant Merge + Actin , 2F mutant NF Expression was detected in spiral ganglion peripheral axons in the base of the cochlea. Defects in type II afferent fibers were observed.
TS28: peripheral nerve fiber Present Regionally restricted 2F mutant Merge + Actin , 2F mutant NF Expression was detected in spiral ganglion peripheral axons in the base of the cochlea. Defects in type II afferent fibers were observed.

Specimen 3A: embryonic day 14.5 (more )
Note: Triple labeled: pink - Nefh; red - Myo7a (assay MGI:8291852); green - Ror1 (assay MGI:8291851).
Structure Level Pattern Image Note
TS22: cochlear ganglion Present Regionally restricted 3A left , 3A center Expression was detected in spiral ganglion axons.
TS22: cochlea Present Regionally restricted 3A right , 3A center Expression was detected in spiral ganglion axons that already invaded the differentiating organ of Corti.
TS22: peripheral nerve fiber Present Regionally restricted 3A right , 3A center Expression was detected in spiral ganglion axons that already invaded the differentiating organ of Corti.

Specimen 3B: embryonic day 17.5 (more )
Note: Triple labeled: pink - Nefh; red - Myo7a (assay MGI:8291852); green - Ror1 (assay MGI:8291851).
Structure Level Pattern Image Note
TS25: cochlear ganglion Present Regionally restricted 3B center , 3B left Expression was detected in spiral ganglion axons.
TS25: organ of Corti Present Regionally restricted 3B center , 3B right Expression was detected in spiral ganglion axons in the organ of Corti.
TS25: peripheral nerve fiber Present Regionally restricted 3B center , 3B right Expression was detected in spiral ganglion axons in the organ of Corti.

Specimen 3C: postnatal day 0 (more )
Note: Triple labeled: pink - Nefh; red - Myo7a (assay MGI:8291852); green - Ror1 (assay MGI:8291851).
Structure Level Pattern Image Note
TS27: cochlear ganglion Present Regionally restricted 3C left , 3C center Expression was detected in spiral ganglion axons.
TS27: organ of Corti Present Regionally restricted 3C right , 3C center Expression was detected in spiral ganglion axons in the organ of Corti.
TS27: peripheral nerve fiber Present Regionally restricted 3C right , 3C center Expression was detected in spiral ganglion axons in the organ of Corti.

Specimen S7B Base WT: postnatal day 5 (more )
Note: Double labeled: cyan - Nefh; red - Phalloidin.
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted S7B WT Base right , S7B WT Base left Immunolabeling showed the afferent innervation pattern at the base of the cochlea.
TS28: peripheral nerve fiber Present Regionally restricted S7B WT Base right , S7B WT Base left Immunolabeling showed the afferent innervation pattern at the base of the cochlea.

Specimen S7B Base Mutant: postnatal day 5; Ror1tm1Ymi/Ror1tm1Ymi (more )
Note: Double labeled: cyan - Nefh; red - Phalloidin.
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted S7B Mutant Base left , S7B Mutant Base right In Ror1 mutant mice, the regular arrangement of type II innervation was impaired and a striking reduction of the density of axons was noticed throughout the organ of Corti.
TS28: peripheral nerve fiber Present Regionally restricted S7B Mutant Base left , S7B Mutant Base right In Ror1 mutant mice, the regular arrangement of type II innervation was impaired and a striking reduction of the density of axons was noticed throughout the organ of Corti.

Specimen S7B Middle WT: postnatal day 5 (more )
Note: Double labeled: cyan - Nefh; red - Phalloidin.
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted S7B WT Middle left , S7B WT Middle right Immunolabeling showed the afferent innervation pattern at the middle of the cochlea.
TS28: peripheral nerve fiber Present Regionally restricted S7B WT Middle left , S7B WT Middle right Immunolabeling showed the afferent innervation pattern at the middle of the cochlea.

Specimen S7B Middle Mutant: postnatal day 5; Ror1tm1Ymi/Ror1tm1Ymi (more )
Note: Double labeled: cyan - Nefh; red - Phalloidin.
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted S7B Mutant Middle left , S7B Mutant Middle right In Ror1 mutant mice, the regular arrangement of type II innervation was impaired and a striking reduction of the density of axons was noticed throughout the organ of Corti.
TS28: peripheral nerve fiber Present Regionally restricted S7B Mutant Middle left , S7B Mutant Middle right In Ror1 mutant mice, the regular arrangement of type II innervation was impaired and a striking reduction of the density of axons was noticed throughout the organ of Corti.

Specimen S7B Apex WT: postnatal day 5 (more )
Note: Double labeled: cyan - Nefh; red - Phalloidin.
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted S7B WT Apex left , S7B WT Apex right Immunolabeling showed the afferent innervation pattern at the apex of the cochlea.
TS28: peripheral nerve fiber Present Regionally restricted S7B WT Apex left , S7B WT Apex right Immunolabeling showed the afferent innervation pattern at the apex of the cochlea.

Specimen S7B Apex Mutant: postnatal day 5; Ror1tm1Ymi/Ror1tm1Ymi (more )
Note: Double labeled: cyan - Nefh; red - Phalloidin.
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted S7B Mutant Apex left , S7B Mutant Apex right In Ror1 mutant mice, the regular arrangement of type II innervation was impaired and a striking reduction of the density of axons was noticed throughout the organ of Corti. In the apex, some axons aberrantly turned toward the apex in the mutant cochlea.
TS28: peripheral nerve fiber Present Regionally restricted S7B Mutant Apex left , S7B Mutant Apex right In Ror1 mutant mice, the regular arrangement of type II innervation was impaired and a striking reduction of the density of axons was noticed throughout the organ of Corti. In the apex, some axons aberrantly turned toward the apex in the mutant cochlea.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/06/2026
MGI 6.29
The Jackson Laboratory