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Gene Expression Data
Assay Details
Assay
Reference: J:290119 Soleilhavoup C, et al., Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun. 2020 Jun 19;11(1):3111
Assay type: RNA in situ
MGI Accession ID: MGI:8270648
Gene symbol: Tle4
Gene name: transducin-like enhancer of split 4
Probe: Grg4 cDNA
Probe preparation: Antisense RNA
Assay notes: Nolz1-/- mutant embryos, in which the coding region of Nolz1 has been replaced by beta-Galactosidase (also referred to as Nolz1<bgal/bgal>). Zfp503<tm1.1Bpb> (neo cassette removed) has been used in the annotations, but it could be Zfp503<tm1Bpb> (neo cassette still present).
Results
Specimen 3e WT: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Present Regionally restricted 3e WT Grg4 Tle4 (Grg4) is a striatopallidal neuron specific gene.
Specimen 3e Nolz1-/-: embryonic day 15.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Strong Regionally restricted 3e Nolz1-/- Grg4 Expression was upregulated in the E15.5 Nolz1-/- mutant striatum.
Specimen 4b WT: embryonic day 12.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: corpus striatum striatum neuron Present Regionally restricted 4b WT Grg4 Expression is detected in striatopallidal projection neurons.
Specimen 4b Nolz1-/-: embryonic day 12.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Structure Cell Type Level Pattern Image Note
TS20: corpus striatum striatum neuron Strong Regionally restricted 4b Nolz1-/- Grg4 Expression is upregulated in striatopallidal projection neurons in the mutant.
Specimen 5h WT: embryonic day 15.5 (more )
Note: Controls were either: Cre+, Cre+;Nolz1fl/+, or Nolz1fl/fl.
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Present Regionally restricted 5h WT Grg4 Expression is in striatopallidal neurons.
Specimen 5h FoxG1-IRES-Cre;Nolz1fl/fl: embryonic day 15.5; Foxg1tm1.1(cre)Ddmo/Foxg1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Present Regionally restricted 5h FoxG1-IresCre;Nolz1fl/fl Grg4 Expression was upregulated in the FoxG1-IRES-Cre;Nolz1<fl/fl> mutant striatum.
Specimen S5i WT: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: corpus striatum Present S5i WT Grg4
Specimen S5i EnCre;Nolz1fl/fl: embryonic day 15.5; En1tm2(cre)Wrst/En1+, Zfp503tm1.1Pnmn/Zfp503tm1.1Pnmn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: corpus striatum Present S5i En1Cre;Nolz1fl/fl Grg4 No expression change was observed in the EnCre;Nolz1<fl/fl> mutant striatum.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
MGI 6.29 		The Jackson Laboratory