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Gene Expression Data
Assay Details
Assay
Reference: J:321503 Meuser M, et al., FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development. Development. 2022 Jan 1;149(1):dev200021
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8262794
Gene symbol: Trp63
Gene name: transformation related protein 63
Antibody: Anti-deltaNp63 (619001)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to Alexa Fluor 555
Results
Specimen 2C +/+;Fgfr1fl/+;Fgfr2fl/+: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2+ (more )
Note: Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter basal cell of urothelium Present 2C +/+;Fgfr1fl/+;Fgfr2fl/+ deltaNP63/KRT5 Expression was detected in B-cells (KRT5+deltaNP63+UPK1B-).
TS26: urothelium of ureter intermediate cell of urothelium Present 2C +/+;Fgfr1fl/+;Fgfr2fl/+ deltaNP63/KRT5 Expression was detected in I-cells (KRT5-deltaNP63+UPK1B+).
TS26: urothelium of ureter umbrella cell of urothelium Absent 2C +/+;Fgfr1fl/+;Fgfr2fl/+ deltaNP63/KRT5 Expression was not detected in S-cells (KRT5-deltaNP63-UPK1B+).
Specimen 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/+: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2+, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter basal cell of urothelium Present 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/+ deltaNP63/KRT5 Expression was detected in B-cells (KRT5+deltaNP63+UPK1B-).
TS26: urothelium of ureter intermediate cell of urothelium Present 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/+ deltaNP63/KRT5 Expression was detected in I-cells (KRT5-deltaNP63+UPK1B+).
TS26: urothelium of ureter umbrella cell of urothelium Absent 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/+ deltaNP63/KRT5 Expression was not detected in S-cells (KRT5-deltaNP63-UPK1B+).
Specimen 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/+: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1tm5.1Sor, Fgfr2tm1Dor/Fgfr2+, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter basal cell of urothelium Present 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/+ deltaNP63/KRT5 Expression was detected in B-cells (KRT5+deltaNP63+UPK1B-).
TS26: urothelium of ureter intermediate cell of urothelium Present 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/+ deltaNP63/KRT5 Expression was detected in I-cells (KRT5-deltaNP63+UPK1B+).
TS26: urothelium of ureter umbrella cell of urothelium Absent 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/+ deltaNP63/KRT5 Expression was not detected in S-cells (KRT5-deltaNP63-UPK1B+).
Specimen 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/fl: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1tm5.1Sor, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter umbrella cell of urothelium Absent 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/fl deltaNP63/KRT5 In mutants with a complete loss of Fgfr2, the mono-layered epithelium expressed the S-cell marker UPK1B, whereas KRT5- and deltaNP63-expressing B and I cells were largely absent.
Specimen 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/fl left: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter umbrella cell of urothelium Absent 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/fl deltaNP63/KRT5 left In mutants with a complete loss of Fgfr2, the mono-layered epithelium expressed the S-cell marker UPK1B, whereas KRT5- and deltaNP63-expressing B and I cells were largely absent.
Specimen 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/fl right: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant. Undilated ureter. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter umbrella cell of urothelium Absent 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/fl deltaNP63/KRT5 right In mutants with a complete loss of Fgfr2, the mono-layered epithelium expressed the S-cell marker UPK1B, whereas KRT5- and deltaNP63-expressing B and I cells were largely absent.
Specimen 3B E12.5 control: embryonic day 12.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Level Pattern Image Note
TS20: epithelial layer of ureter Absent 3B control E12.5 deltaNP63/KRT5
Specimen 3B E12.5 Fgfr2cKO: embryonic day 12.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Level Pattern Image Note
TS20: epithelial layer of ureter Absent 3B Fgfr2cKO E12.5 deltaNP63/KRT5
Specimen 3B E14.5 control: embryonic day 14.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Level Pattern Image Note
TS22: urothelium of ureter Present 3B control E14.5 deltaNP63/KRT5
Specimen 3B E14.5 Fgfr2cKO: embryonic day 14.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Level Pattern Image Note
TS22: urothelium of ureter Absent 3B Fgfr2cKO E14.5 deltaNP63/KRT5 The ureter epithelium appeared less stratified at E14.5, and did not activate expression of deltaNP63 and KRT5.
Specimen 3B E15.5 control: embryonic day 15.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Level Pattern Image Note
TS23: urothelium of ureter Present 3B control E15.5 deltaNP63/KRT5
Specimen 3B E15.5 Fgfr2cKO: embryonic day 15.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Level Pattern Image Note
TS23: urothelium of ureter Absent 3B Fgfr2cKO E15.5 deltaNP63/KRT5 The ureter epithelium appeared less stratified, and did not activate expression of deltaNP63 and KRT5.
Specimen 3B E16.5 control: embryonic day 16.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Level Pattern Image Note
TS24: urothelium of ureter Present 3B control E16.5 deltaNP63/KRT5
Specimen 3B E16.5 Fgfr2cKO: embryonic day 16.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant. Double labeled: red - Trp63; green - Krt5 (assay MGI:8262792).
Structure Level Pattern Image Note
TS24: urothelium of ureter Absent 3B Fgfr2cKO E16.5 deltaNP63/KRT5 The ureter epithelium appeared less stratified, and did not activate expression of deltaNP63 and KRT5.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
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