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Gene Expression Data
Assay Details
Assay
Reference: J:321503 Meuser M, et al., FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development. Development. 2022 Jan 1;149(1):dev200021
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8262787
Gene symbol: Cdh1
Gene name: cadherin 1
Antibody: anti-Cdh1
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to Alexa Fluor 488
Results
Specimen 2C +/+;Fgfr1fl/+;Fgfr2fl/+: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2+ (more )
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter ureter urothelial cell Present Regionally restricted 2C +/+;Fgfr1fl/+;Fgfr2fl/+ CDH1 CDH1 is a marker of the lateral-basal membrane of epithelial cells.
Specimen 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/+: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2+, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter ureter urothelial cell Present Regionally restricted 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/+ CDH1 Expression was detected in the lateral-basal membrane of epithelial cells.
Specimen 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/+: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1tm5.1Sor, Fgfr2tm1Dor/Fgfr2+, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter ureter urothelial cell Present Regionally restricted 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/+ CDH1 Expression was detected in the lateral-basal membrane of epithelial cells.
Specimen 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/fl: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1tm5.1Sor, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter ureter urothelial cell Present Regionally restricted 2C Pax2-cre/+;Fgfr1fl/fl;Fgfr2fl/fl CDH1 Expression was detected in the lateral-basal membrane of epithelial cells, but the epithelium appeared mono-layered in mutants with loss of two alleles of Fgfr2.
Specimen 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/fl left: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter ureter urothelial cell Present Regionally restricted 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/fl CDH1 left Expression was detected in the lateral-basal membrane of epithelial cells, but the epithelium appeared mono-layered in mutants with loss of two alleles of Fgfr2.
Specimen 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/fl right: embryonic day 18.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant. Undilated ureter.
Structure Cell Type Level Pattern Image Note
TS26: urothelium of ureter ureter urothelial cell Present Regionally restricted 2C Pax2-cre/+;Fgfr1fl/+;Fgfr2fl/fl CDH1 right Expression was detected in the lateral-basal membrane of epithelial cells, but the epithelium appeared mono-layered in mutants with loss of two alleles of Fgfr2.
Specimen 3B E12.5 control: embryonic day 12.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls.
Structure Level Pattern Image Note
TS20: epithelial layer of ureter Present 3B control E12.5 CDH1
Specimen 3B E12.5 Fgfr2cKO: embryonic day 12.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: epithelial layer of ureter Present 3B Fgfr2cKO E12.5 CDH1
Specimen 3B E14.5 control: embryonic day 14.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls.
Structure Level Pattern Image Note
TS22: urothelium of ureter Present 3B control E14.5 CDH1
Specimen 3B E14.5 Fgfr2cKO: embryonic day 14.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: urothelium of ureter Present 3B Fgfr2cKO E14.5 CDH1 The ureter epithelium appeared less stratified at E14.5 and subsequent stages.
Specimen 3B E15.5 control: embryonic day 15.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls.
Structure Level Pattern Image Note
TS23: urothelium of ureter Present 3B control E15.5 CDH1
Specimen 3B E15.5 Fgfr2cKO: embryonic day 15.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: urothelium of ureter Present Regionally restricted 3B Fgfr2cKO E15.5 CDH1 The ureter epithelium appeared less stratified.
Specimen 3B E16.5 control: embryonic day 16.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls.
Structure Level Pattern Image Note
TS24: urothelium of ureter Present 3B control E16.5 CDH1
Specimen 3B E16.5 Fgfr2cKO: embryonic day 16.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: urothelium of ureter Present 3B Fgfr2cKO E16.5 CDH1 The ureter epithelium appeared less stratified.
Specimen S4B control E12.5: embryonic day 12.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls.
Structure Level Pattern Image Note
TS20: epithelial layer of ureter Present S4B E12.5 control
Specimen S4B Fgfr2cKO E12.5: embryonic day 12.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: epithelial layer of ureter Present S4B E12.5 Fgfr2cKO
Specimen S4B control E14.5: embryonic day 14.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls.
Structure Level Pattern Image Note
TS22: urothelium of ureter Present S4B E14.5 control
Specimen S4B Fgfr2cKO E14.5: embryonic day 14.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: urothelium of ureter Present S4B E14.5 Fgfr2cKO The ureter epithelium appeared less stratified at E14.5 and subsequent stages.
Specimen S4B control E15.5: embryonic day 15.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls.
Structure Level Pattern Image Note
TS23: urothelium of ureter Present S4B E15.5 control
Specimen S4B Fgfr2cKO E15.5: embryonic day 15.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: urothelium of ureter Present S4B E15.5 Fgfr2cKO The ureter epithelium appeared less stratified.
Specimen S4B control E16.5: embryonic day 16.5; Fgfr1tm5.1Sor/?, Fgfr2tm1Dor/? (more )
Note: Cre-negative littermates were used as controls.
Structure Level Pattern Image Note
TS24: urothelium of ureter Present S4B E16.5 control
Specimen S4B Fgfr2cKO E16.5: embryonic day 16.5; Fgfr1tm5.1Sor/Fgfr1+, Fgfr2tm1Dor/Fgfr2tm1Dor, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: urothelium of ureter Present S4B E16.5 Fgfr2cKO The ureter epithelium appeared less stratified.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
MGI 6.29 		The Jackson Laboratory