Yap1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:307319 George NM, et al., Exploiting Expression of Hippo Effector, Yap, for Expansion of Functional Islet Mass. Mol Endocrinol. 2015 Nov;29(11):1594-607
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8258984
Gene symbol:	Yap1
Gene name:	yes-associated protein 1

Antibody:	anti-YAP1 ( YAP1 8J19)
Assay notes:	The authors did not specify which antibody was used, Anti-YAP1 (13584-1-AP) MGI:8248886 may have been used instead.

Results

Specimen 1A Mst1^lox/lox/Mst2^lox/lox Yap: postnatal; Stk3^tm1.1Rjo/Stk3^tm1.1Rjo, Stk4^tm1.1Rjo/Stk4^tm1.1Rjo (more

)
Note: Double labeled: red - Yap1; green - Ins1 (assay MGI:8258979) and Ins2 (assay MGI:8258985).

Structure	Level	Pattern	Image	Note
TS28: pancreatic duct	Present		1A Mst1^lox/lox/Mst2^lox/lox Yap top , 1A Mst1^lox/lox/Mst2^lox/lox Yap bottom
TS28: islets of Langerhans	Absent		1A Mst1^lox/lox/Mst2^lox/lox Yap bottom , 1A Mst1^lox/lox/Mst2^lox/lox Yap top

Specimen 1A Ins-Cre/Mst1^lox/lox/Mst2^lox/lox Yap: postnatal; Stk3^tm1.1Rjo/Stk3^tm1.1Rjo, Stk4^tm1.1Rjo/Stk4^tm1.1Rjo, Tg(Ins2-cre)25Mgn/0 (more

)
Note: Conditional mutant. Double labeled: red - Yap1; green - Ins1 (assay MGI:8258979) and Ins2 (assay MGI:8258985).

Structure	Level	Pattern	Image	Note
TS28: pancreatic duct	Present		1A Ins-Cre/Mst1^lox/lox/Mst2^lox/lox Yap top , 1A Ins-Cre/Mst1^lox/lox/Mst2^lox/lox Yap bottom
TS28: islets of Langerhans	Absent		1A Ins-Cre/Mst1^lox/lox/Mst2^lox/lox Yap bottom , 1A Ins-Cre/Mst1^lox/lox/Mst2^lox/lox Yap top

Specimen 2A left: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: pancreas	Strong	Regionally restricted	2A left	Expression is in trunk epithelial cells.

Specimen 2A right: embryonic day 16.5 (more

)
Note: Double labeled: red - Yap1; green - Neurog3 (assay MGI:8259002).

Structure	Level	Pattern	Image	Note
TS24: pancreas	Strong	Regionally restricted	2A right	Expression is in trunk epithelial cells.

Specimen 2D: embryonic day 16.5 (more

)
Note: Double labeled: red - Yap1; green - Mki67 (assay MGI:8259006).

Structure	Level	Pattern	Image	Note
TS24: pancreas	Present		2D right , 2D left

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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