Pou4f2 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:372845 Napoli FR, et al., Microphthalmia and Disrupted Retinal Development Due to a LacZ Knock-in/Knock-Out Allele at the Vsx2 Locus. Eye Brain. 2024;16:115-131
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8257026
Gene symbol:	Pou4f2
Gene name:	POU domain, class 4, transcription factor 2

Antibody:

anti-Brn-3 (C-13): sc-6026

Results

4C ©

Specimen 4C: embryonic day 12.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS20: retina	retinal ganglion cell	Present		4C

4I ©

Specimen 4I: embryonic day 12.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS20: retina	Absent		4I	No expression in central retina at E12.5

Specimen +/Z not shown: embryonic day 13.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS21: retina	Present

Specimen Z/Z not shown: embryonic day 13.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS21: retina	Absent			Expression not detected in central retina at E13.5.

4O ©

Specimen 4O: embryonic day 15.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS23: retina	Present		4O

4U ©

Specimen 4U: embryonic day 15.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS23: retina	Present	Regionally restricted	4U	Expression centrally restricted at E15.5

7I ©

Specimen 7I: postnatal day 0; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS27: retina	Present		7I

7J ©

Specimen 7J: postnatal day 0; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS27: retina	Present	Regionally restricted	7J	Expressed in a disorganized manner.

8I ©

Specimen 8I: postnatal day 10; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS28: retina	Present		8I

8J ©

Specimen 8J: postnatal day 10; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS28: retina	Present	Regionally restricted	8J	Disorganized pattern of new neurons,.

9I ©

Specimen 9I: postnatal day 28; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS28: retina	Present		9I

9J ©

Specimen 9J: postnatal day 28; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: retina	retinal ganglion cell	Present	Regionally restricted	9J	Aberrantly proliferating cells interspersed with progenitors, differentiating neuronal cells, Muller glia, retinal ganglion cells, amacrine cells and photoreceptors.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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