Tubb3 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:372845 Napoli FR, et al., Microphthalmia and Disrupted Retinal Development Due to a LacZ Knock-in/Knock-Out Allele at the Vsx2 Locus. Eye Brain. 2024;16:115-131
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8257023
Gene symbol:	Tubb3
Gene name:	tubulin, beta 3 class III

Antibody:

anti-Tuj1 (rabbit polyclonal 802001)

Results

4A ©

Specimen 4A: embryonic day 12.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS20: retina	Present		4A

4G ©

Specimen 4G: embryonic day 12.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS20: retina	Absent		4G	No expression in central retina at E12.5

4M ©

Specimen 4M: embryonic day 15.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS23: retina	Present		4M

4S ©

Specimen 4S: embryonic day 15.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS23: retina	Present	Regionally restricted	4S	Expression cenrally restricted at E15.5

5D left ©

5D right ©

Specimen 5D: embryonic day 15.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS23: retina	Present		5D right , 5D left

5E left ©

5E right ©

Specimen 5E: embryonic day 15.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS23: retina	Present	Regionally restricted	5E left , 5E right	Expression centrally restricted at E15.5 and seemingly covaries with micropthalmia severity.

5F left ©

5F right ©

Specimen 5F: embryonic day 15.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS23: retina	Present	Regionally restricted	5F left , 5F right	Expression centrally restricted at E15.5 and seemingly covaries with micropthalmia severity.

5G left ©

5G right ©

Specimen 5G: embryonic day 15.5; Vsx2^or-J/Vsx2^or-J (more

)

Structure	Level	Pattern	Image	Note
TS23: retina	Present		5G right , 5G left

5N left ©

5N right ©

Specimen 5N: embryonic day 13.5; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS21: retina	Present		5N right , 5N left	Neurogenesis initiates at E13.5 in LacZ mutant.

5O left ©

5O right ©

Specimen 5O: embryonic day 13.25; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS21: retina	Present		5O left , 5O right

5P left ©

5P right ©

Specimen 5P: embryonic day 13.25; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS21: retina	Absent		5P right , 5P left	Expression not observed at E13.25 in LacZ mutant.

5Q left ©

5Q right ©

Specimen 5Q: embryonic day 13.25; Vsx2^or-J/Vsx2^or-J (more

)

Structure	Level	Pattern	Image	Note
TS21: retina	Present		5Q right , 5Q left	Neurogenesis initiates by E13.25 in orj mutant.

7E ©

Specimen 7E: postnatal day 0; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS27: retina	Present		7E

7F ©

Specimen 7F: postnatal day 0; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS27: retina	Present	Regionally restricted	7F	Expressed in a disorganized manner.

8E ©

Specimen 8E: postnatal day 10; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS28: retina	Present		8E

8F ©

Specimen 8F: postnatal day 10; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS28: retina	Present	Regionally restricted	8F	Disorganized pattern of new neurons,.

9E ©

Specimen 9E: postnatal day 28; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2⁺ (more

)

Structure	Level	Pattern	Image	Note
TS28: retina	Present		9E

9F ©

Specimen 9F: postnatal day 28; Vsx2^{tm1b(EUCOMM)Wtsi}/Vsx2^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS28: retina	Present	Regionally restricted	9F	Aberrantly proliferating cells interspersed with progenitors, differentiating neuronal cells, Muller glia, retinal ganglion cells, amacrine cells and photoreceptors.

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