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Gene Expression Data
Assay Details
Assay
Reference: J:157028 Laine H, et al., Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors. Dev Biol. 2010 Jan 1;337(1):134-46
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8235840
Gene symbol: Ccnd1
Gene name: cyclin D1
Antibody: anti-cyclin D1
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 4b: postnatal day 1 (more )
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti cochlea auditory hair cell Absent 4b No expression in hair cells of organ of Corti.
TS27: cochlea Deiter's cell Absent 4b No expression in Deiter's cells.
TS27: cochlea supporting cell of cochlea Present Regionally restricted 4b Expression in other supporting cells.

Specimen P2 not shown: postnatal day 2 (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct cochlea auditory hair cell Trace Regionally restricted Transient upregulated of expression in cochlear hair cells first very weakly seen in upper basal part at P2.

Specimen 4c: postnatal day 3 (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct cochlea auditory hair cell Present Regionally restricted 4c No expression in hair cells in middle part.

Specimen 4d: postnatal day 3 (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct cochlea auditory hair cell Present Regionally restricted 4d Expression transiently upregulated in cochlear hair cells. Increased expression in upper basal part.

Specimen 4e: postnatal day 4 (more )
Structure Level Pattern Image Note
TS28: cochlear duct Present Regionally restricted 4e Expression does not extend into apex.

Specimen 4f: postnatal day 4 (more )
Structure Level Pattern Image Note
TS28: cochlear duct Present Regionally restricted 4f Expression extends into middle part of cochlea.

Specimen 4g: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct cochlear inner hair cell Present Regionally restricted 4g Expression localized to inner hair cells and outer hair cells of upper basal and middle regions.
TS28: cochlear duct cochlear outer hair cell Present Regionally restricted 4g Expression localized to inner hair cells and outer hair cells of upper basal and middle regions.

Specimen 4h: postnatal day 10 (more )
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct cochlear inner hair cell Present Regionally restricted 4h Expression downregulated. Expression in several inner hair cells but only a few outer hair cells
TS28: cochlear duct cochlear outer hair cell Present Regionally restricted 4h Expression downregulated. Expression in several inner hair cells but only a few outer hair cells

Specimen 4i: postnatal day 15 (more )
Structure Cell Type Level Pattern Image Note
TS28: cochlear duct cochlea auditory hair cell Absent 4i Expression undetectable in cochlear hair cells.
TS28: cochlea supporting cell of cochlea Weak Single cells 4i Expression in a few laterally located supporting cells.

Specimen 4j: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: semicircular duct ampulla vestibular hair cell Present Regionally restricted 4j No expression in majority of utricular hair cells.
TS27: utricle vestibular hair cell Present Regionally restricted 4j No expression in majority of utricular hair cells.
TS27: utricle supporting cell of vestibular epithelium Strong Uniform 4j Prominent homogeneous expression in supporting cells.

Specimen 4k: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: utricle supporting cell of vestibular epithelium Present Regionally restricted 4k Expression maintained in small part of supporting cells.
TS28: utricle vestibular hair cell Present Regionally restricted 4k Expression in a few hair cells.

Specimen 4l: postnatal day 60 (more )
Structure Cell Type Level Pattern Image Note
TS28: utricle supporting cell of vestibular epithelium Present Regionally restricted 4l Expression maintained in small part of supporting cells.
TS28: utricle vestibular hair cell Present Regionally restricted 4l Expression in a few hair cells.

Specimen 6a: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cochlear duct epithelium Present Widespread 6a Widely expressed in cochlear duct epithelium, including prosensory domain lacking Mki67 expression.

Specimen 6c: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: cochlear duct cochlea auditory hair cell Weak Regionally restricted 6c Expression downregulated in differentiated hair cells of basal part, but not in undifferentiated part of cochlea.

Specimen 6d,e: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: cochlear duct epithelium cochlea auditory hair cell Weak Graded 6e , 6d Expression downregulated in differentiated hair cells of basal part, but not in undifferentiated part of cochlea.
TS24: organ of Corti cochlear inner hair cell Absent 6d , 6e No expression in first emerging inner hair cells.
TS24: organ of Corti cochlear outer hair cell Weak 6d , 6e Decreased expression in outer hair cels.
TS24: cochlea supporting cell of cochlea Present Regionally restricted 6d , 6e Expression in different types of supporting cells.
TS24: cochlea Deiter's cell Weak Graded 6d , 6e Initiation of downregulation in Deiter's cells, in a base-to-apex gradient.

Specimen P1 not shown: postnatal day 1 (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct cochlea auditory hair cell Weak Regionally restricted Suppression of expression reached hair cells in apical region by P1.

Specimen 6f: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: utricle Present Widespread 6f Broadly expressed in vestibular epithelia.

Specimen 6h: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: utricle vestibular hair cell Weak Regionally restricted 6h Expression disappeared from majority of differentiated utricular hair cells.
TS24: utricle supporting cell of vestibular epithelium Strong 6h Strong expression persists in supporting cells.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/06/2026
MGI 6.29
The Jackson Laboratory