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Gene Expression Data
Assay Details
Assay
Reference: J:284927 Roberts NA, et al., Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder. Kidney Int. 2019 May;95(5):1138-1152
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8212980
Gene symbol: Nos1
Gene name: nitric oxide synthase 1, neuronal
Antibody: anti-nNOS (AF2416)
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 7a WT: postnatal week 2 (more )
Note: Bladders were opened ventrally. Quantified in Fig 7b.
Structure Level Pattern Image Note
TS28: nerve of bladder neck Present 7a WT nNos Expressed in nitrergic parasympathetic nerves. Expressed in fine bundles connecting the pelvic ganglia.
TS28: pelvic ganglion Present Regionally restricted 7a WT nNos Expressed in a subset of cell bodies.
Specimen 7a Lrig2-/-: postnatal week 2; Lrig2tm1.1Hhed/Lrig2tm1.1Hhed (more )
Note: Bladders were opened ventrally. Quantified in Fig 7b.
Structure Level Pattern Image Note
TS28: pelvic ganglion Present Regionally restricted 7a Lrig2-/- nNos Expressed in a subset of cell bodies, similar as in the wild-type.
TS28: nerve of bladder neck Present 7a Lrig2-/- nNos Patterns of positive connecting nerves appeared aberrant, sometimes with barely any positive processes detected.
Specimen 7a Hpse2-/-: postnatal week 2; Hpse2Gt(OST441123)Lex/Hpse2Gt(OST441123)Lex (more )
Note: Bladders were opened ventrally. Quantified in Fig 7b.
Structure Level Pattern Image Note
TS28: nerve of bladder neck Present 7a Hpse2-/- nNos Patterns of positive connecting nerves appeared aberrant, sometimes with barely any positive processes detected.
TS28: pelvic ganglion Present Regionally restricted 7a Hpse2-/- nNos Expressed in a subset of cell bodies, similar as in the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/15/2026
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