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Gene Expression Data
Assay Details
Assay
Reference: J:253351 Hanley O, et al., Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns. Neuron. 2016 Sep 7;91(5):1005-1020
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8207781
Gene symbol: Aldh1a2
Gene name: aldehyde dehydrogenase family 1, subfamily A2
Antibody: Anti-Raldh2
Results
Specimen 2B Control: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Present Regionally restricted 2B Control Expression was detected in lateral motor column neurons.
Specimen 2B PbxMNdelta: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region spinal cord motor neuron Trace Regionally restricted 2B PbxMNdelta A dramatic reduction of expression was observed in the lateral motor column neurons.
Specimen S2A Pbx3+/-: embryonic day 12.5; Pbx3tm1Mlc/Pbx3+ (more )
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present S2A Raldh2 Pbx3+/-
Specimen S2A Pbx3-/-: embryonic day 12.5; Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present S2A Raldh2 Pbx3-/- Lateral motor column differentiation is preserved in Pbx3-/- mice at E12.5.
Specimen S2E Control rostral: embryonic day 12.5 (more )
Note: Double labeled: red - Aldh1a2; green - Foxp1 (assay MGI:8206371).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2E rostral Control
Specimen S2E Pbx1MNdelta rostral: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: red - Aldh1a2; green - Foxp1 (assay MGI:8206371).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present Regionally restricted S2E rostral Pbx1MNdelta There was a reduction in Foxp1+ Raldh2+ lateral motor column neurons in Pbx1MNdelta mutants.
Specimen S2E Control middle: embryonic day 12.5 (more )
Note: Double labeled: red - Aldh1a2; green - Foxp1 (assay MGI:8206371).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2E Control
Specimen S2E Pbx1MNdelta middle: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: red - Aldh1a2; green - Foxp1 (assay MGI:8206371).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present Regionally restricted S2E Pbx1MNdelta There was a reduction in Foxp1+ Raldh2+ lateral motor column neurons in Pbx1MNdelta mutants.
Specimen S2E Control caudal: embryonic day 12.5 (more )
Note: Double labeled: red - Aldh1a2; green - Foxp1 (assay MGI:8206371).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2E caudal Control
Specimen S2E Pbx1MNdelta caudal: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: red - Aldh1a2; green - Foxp1 (assay MGI:8206371).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present Regionally restricted S2E caudal Pbx1MNdelta There was a reduction in Foxp1+ Raldh2+ lateral motor column neurons in Pbx1MNdelta mutants.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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