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Gene Expression Data
Assay Details
Assay
Reference: J:360776 Di Michele M, et al., E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development. Nat Commun. 2025 Jan 2;16(1):67
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8188164
Gene symbol: Casp3
Gene name: caspase 3
Results
Specimen 2B E14.5 CTL: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forebrain Absent 2B E14.5 CTL , 2B E14.5 CTL inset
Specimen 2B E14.5 KO: embryonic day 14.5; E4f1tm1.1Llca/E4f1tm1.1Llca, Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: forebrain Trace 2B E14.5 KO inset , 2B E14.5 KO Very mild increase in expression at E14.5
Specimen 2B E16.5 CTL: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: forebrain Absent 2B E16.5 CTL inset , 2B E16.5 CTL
Specimen 2B E16.5 KO: embryonic day 16.5; E4f1tm1.1Llca/E4f1tm1.1Llca, Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: forebrain Present 2B E16.5 KO , 2B E16.5 KO inset Enhanced cleavage seen at E16.5.
Specimen 2B E18.5 CTL: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: forebrain Absent 2B E18.5 CTL , 2B E18.5 CTL inset
Specimen 2B E18.5 KO: embryonic day 18.5; E4f1tm1.1Llca/E4f1tm1.1Llca, Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: forebrain Present 2B E18.5 KO , 2B E18.5 KO inset Enhanced cleavage seen at E16.5.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
MGI 6.29 		The Jackson Laboratory