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Gene Expression Data
Assay Details
Assay
Reference: J:360776 Di Michele M, et al., E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development. Nat Commun. 2025 Jan 2;16(1):67
Assay type: Western blot
MGI Accession ID: MGI:8188153
Gene symbol: Casp3
Gene name: caspase 3
Results
Image: 2A CASP3 ©

 Sample Information Bands Other Sample Information
Lane AgeStructure Size Not Specified (a) Size Not Specified (b) Genetic BackgroundMutant Allele(s)Sex Note
E14.5 CTL #1 E14.5 TS22: brain Present Absent involves: 129/Sv * C57BL/6J Not Specified
E14.5 KO #1 E14.5 TS22: brain Present Ambiguous (c) involves: 129/Sv * C57BL/6 * C57BL/6J * SJL E4f1tm1.1Llca/E4f1tm1.1Llca, Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+, Tg(Nes-cre)1Kln/0Not Specified Conditional mutant.
E14.5 CTL #2 E14.5 TS22: brain Present Absent involves: 129/Sv * C57BL/6J Not Specified
E14.5 KO #2 E14.5 TS22: brain Present Ambiguous (c) involves: 129/Sv * C57BL/6 * C57BL/6J * SJL E4f1tm1.1Llca/E4f1tm1.1Llca, Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+, Tg(Nes-cre)1Kln/0Not Specified Conditional mutant.
E16.5 CTL #1 E16.5 TS24: brain Present Ambiguous involves: 129/Sv * C57BL/6J Not Specified
E16.5 KO #1 E16.5 TS24: brain Present Strong (d) involves: 129/Sv * C57BL/6 * C57BL/6J * SJL E4f1tm1.1Llca/E4f1tm1.1Llca, Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+, Tg(Nes-cre)1Kln/0Not Specified Conditional mutant.
E16.5 CTL #2 E16.5 TS24: brain Present Ambiguous involves: 129/Sv * C57BL/6J Not Specified
E16.5 KO #2 E16.5 TS24: brain Present Present (d) involves: 129/Sv * C57BL/6 * C57BL/6J * SJL E4f1tm1.1Llca/E4f1tm1.1Llca, Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+, Tg(Nes-cre)1Kln/0Not Specified Conditional mutant.
E18.5 CTL #1 E18.5 TS26: brain Present Ambiguous involves: 129/Sv * C57BL/6J Not Specified
E18.5 KO #1 E18.5 TS26: brain Present Strong (d) involves: 129/Sv * C57BL/6 * C57BL/6J * SJL E4f1tm1.1Llca/E4f1tm1.1Llca, Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+, Tg(Nes-cre)1Kln/0Not Specified Conditional mutant.
E18.5 CTL #2 E18.5 TS26: brain Present Ambiguous involves: 129/Sv * C57BL/6J Not Specified
E18.5 KO #2 E18.5 TS26: brain Present Strong (d) involves: 129/Sv * C57BL/6 * C57BL/6J * SJL E4f1tm1.1Llca/E4f1tm1.1Llca, Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+, Tg(Nes-cre)1Kln/0Not Specified Conditional mutant.
Notes:
(a) CASP3
(b) C-CASP3
(c) Authors report very mild increase in expression at E14.5.
(d) Authors report enhanced cleavage at E16.5 and E18.5 compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
MGI 6.29 		The Jackson Laboratory