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Gene Expression Data
Assay Details
Assay
Reference: J:178173 Mastracci TL, et al., Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol. 2011 Nov 1;359(1):1-11
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8161699
Gene symbol: Sst
Gene name: somatostatin
Antibody: anti-somatostatin
Detection system: Secondary antibody coupled to Cy2
Results
Specimen 5C: embryonic day 12.5 (more )
Note: Double labeled: green - Sst; red - Ghrl (assay MGI:8161663).
Structure Level Pattern Image Note
TS20: pancreas Absent 5C No ghrelin+/somatostatin+ cells were seen.
Specimen 5D: embryonic day 12.5; Arxtm1Gldn/?, Tg(Pdx1-cre)6Tuv/0 (more )
Note: Conditional mutant. Arxtm1Gldn/Arxtm1Gldn in female, Arxtm1Gldn/Y in male. Double labeled: green - Sst; red - Ghrl (assay MGI:8161663).
Structure Level Pattern Image Note
TS20: pancreas Present 5D Precocious somatostatin cells were present. The ghrelin+/somatostatin+ cells were rare.
Specimen 5E: embryonic day 12.5; Nkx2-2tm1Jlr/Nkx2-2tm1Jlr (more )
Note: Double labeled: green - Sst; red - Ghrl (assay MGI:8161663).
Structure Level Pattern Image Note
TS20: pancreas Absent 5E
Specimen 5F: embryonic day 12.5; Arxtm1Gldn/?, Nkx2-2tm1Jlr/Nkx2-2tm1Jlr, Tg(Pdx1-cre)6Tuv/0 (more )
Note: Conditional mutant. Arxtm1Gldn/Arxtm1Gldn in female, Arxtm1Gldn/Y in male. Double labeled: green - Sst; red - Ghrl (assay MGI:8161663).
Structure Level Pattern Image Note
TS20: pancreas Present 5F The population of ghrelin+/somatostatin+ cells was greatly increased.
Specimen 5G: postnatal day 0 (more )
Note: Double labeled: green - Sst; red - Ghrl (assay MGI:8161663).
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic D cell Present 5G No ghrelin+/somatostatin+ cells were seen.
Specimen 5H: postnatal day 0; Arxtm1Gldn/?, Tg(Pdx1-cre)6Tuv/0 (more )
Note: Conditional mutant. Arxtm1Gldn/Arxtm1Gldn in female, Arxtm1Gldn/Y in male. Double labeled: green - Sst; red - Ghrl (assay MGI:8161663).
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic D cell Present 5H Increased expression compared with the wild-type. The ghrelin+/somatostatin+ cells were rare.
Specimen 5I: postnatal day 0; Nkx2-2tm1Jlr/Nkx2-2tm1Jlr (more )
Note: Double labeled: green - Sst; red - Ghrl (assay MGI:8161663).
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic D cell Weak 5I No ghrelin+/somatostatin+ cells were seen.
Specimen 5J: postnatal day 0; Arxtm1Gldn/?, Nkx2-2tm1Jlr/Nkx2-2tm1Jlr, Tg(Pdx1-cre)6Tuv/0 (more )
Note: Conditional mutant. Arxtm1Gldn/Arxtm1Gldn in female, Arxtm1Gldn/Y in male. Double labeled: green - Sst; red - Ghrl (assay MGI:8161663).
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic D cell Present 5J The population of ghrelin+/somatostatin+ cells was greatly increased.
Specimen 6I: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic D cell Present 6I
Specimen 6J: postnatal day 0; Arxtm1Gldn/?, Tg(Neurog3-cre)C1Able/0 (more )
Note: Conditional mutant. Arxtm1Gldn/Arxtm1Gldn in female, Arxtm1Gldn/Y in male.
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic D cell Present 6J Increased expression compared with the wild-type.
Specimen 6K: postnatal day 0; Nkx2-2tm1Jlr/Nkx2-2tm1Jlr (more )
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic D cell Present 6K Similar as in the wild-type.
Specimen 6L: postnatal day 0; Arxtm1Gldn/?, Nkx2-2tm1Jlr/Nkx2-2tm1Jlr, Tg(Neurog3-cre)C1Able/0 (more )
Note: Conditional mutant. Arxtm1Gldn/Arxtm1Gldn in female, Arxtm1Gldn/Y in male.
Structure Cell Type Level Pattern Image Note
TS27: pancreas pancreatic D cell Present 6L Increased expression compared with the wild-type.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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