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Gene Expression Data
Assay Details
Assay
Reference: J:355649 Li Q, et al., Metabolic rewiring during bone development underlies tRNA m7G-associated primordial dwarfism. J Clin Invest. 2024 Sep 10;134(20)
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7864031
Gene symbol: Rps6
Gene name: ribosomal protein S6
Results
Specimen 7H WT: embryonic day 14.5; Mettl1em1Bcgen/? (more )
Note: Mettl1fl/fl mice and Prrx1Cre Mettl1fl/+ mice were used as littermate controls.
Structure Level Pattern Image Note
TS22: humerus cartilage condensation Present 7H WT
Specimen 7H Cre;Mettl1fl/fl: embryonic day 14.5; Mettl1em1Bcgen/Mettl1em1Bcgen, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: humerus cartilage condensation Trace 7H Cre;Mettl1fl/fl Expression markedly reduced compared to wild type.
Specimen S17A WT: postnatal day 0; Mettl1em1Bcgen/? (more )
Note: Mettl1fl/fl mice and Prrx1Cre Mettl1fl/+ mice were used as littermate controls.
Structure Level Pattern Image Note
TS27: humerus Present S17A WT lower right , S17A WT upper right , S17A WT left
Specimen S17A Cre;Tsc1fl/fl: postnatal day 0; Tg(Prrx1-cre)1Cjt/0, Tsc1tm1Djk/Tsc1tm1Djk (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: humerus Present S17A Cre;Tsc1fl/fl upper right , S17A Cre;Tsc1fl/fl left , S17A Cre;Tsc1fl/fl lower right
Specimen S17A Cre;Mettl1fl/fl: postnatal day 0; Mettl1em1Bcgen/Mettl1em1Bcgen, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: humerus Weak S17A Cre;Mettl1fl/fl upper right , S17A Cre;Mettl1fl/fl left , S17A Cre;Mettl1fl/fl lower right
Specimen S17A Cre;Mettl1fl/fl;Tsc1fl/fl: postnatal day 0; Mettl1em1Bcgen/Mettl1em1Bcgen, Tsc1tm1Djk/Tsc1tm1Djk, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: humerus Strong Regionally restricted S17A Cre;Mettl1fl/fl;Tsc1fl/fl lower right , S17A Cre;Mettl1fl/fl;Tsc1fl/fl left , S17A Cre;Mettl1fl/fl;Tsc1fl/fl upper right Much higher level of expression in growth plate chondrocytes.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory