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Gene Expression Data
Assay Details
Assay
Reference: J:359864 Chen Y, et al., The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast proliferation during early development. Development. 2024 Nov 15;151(22):dev202444
Assay type: RNA in situ
MGI Accession ID: MGI:7861721
Gene symbol: Pmel
Gene name: premelanosome protein
Probe: Si cDNA1
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1B E11.5 WT: embryonic day 11.5 (more )
Structure Cell Type Level Pattern Image Note
TS19: tail mesenchyme derived from neural crest melanoblast Present 1B E11.5 WT Expression in migratory melanoblasts
Specimen 1B E11.5 Ednrb-/-: embryonic day 11.5; Ednrbtm1Myks/Ednrbtm1Myks (more )
Structure Cell Type Level Pattern Image Note
TS19: tail mesenchyme derived from neural crest melanoblast Present 1B E11.5 Ednrb-/- No difference in number of melanoblasts compared to wild type.
Specimen 1B E12.0 WT: embryonic day 12.0 (more )
Structure Cell Type Level Pattern Image Note
TS20: tail mesenchyme derived from neural crest melanoblast Strong 1B E12.0 WT Significant increase in number of melanoblasts compared to earlier stage.
Specimen 1B E12.0 Ednrb-/-: embryonic day 12.0; Ednrbtm1Myks/Ednrbtm1Myks (more )
Structure Level Pattern Image Note
TS20: tail mesenchyme derived from neural crest Strong 1B E12.0 Ednrb-/- Significant decrease in number of melanoblasts compared to wild type.
Specimen 1B E12.5 WT: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: tail mesenchyme derived from neural crest Strong 1B E12.5 WT Significant increase in number of melanoblasts compared to earlier stage.
Specimen 1B E12.5 Ednrb-/-: embryonic day 12.5; Ednrbtm1Myks/Ednrbtm1Myks (more )
Structure Cell Type Level Pattern Image Note
TS20: tail mesenchyme derived from neural crest melanoblast Present 1B E12.5 Ednrb-/- Significant decrease in number of melanoblasts compared to wild type.
Specimen S1B E11.5 WT: embryonic day 11.5 (more )
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Present S1B A Number of melanoblasts significantly higher than Ednrb-/- at each stage.
Specimen S1B E11.5 Ednrb-/-: embryonic day 11.5; Ednrbtm1Myks/Ednrbtm1Myks (more )
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Weak S1B B Expression in melanoblasts reduced compared to wild type.
Specimen S1B E12.0 WT: embryonic day 12.0 (more )
Structure Cell Type Level Pattern Image Note
TS20: mesenchyme derived from neural crest melanoblast Strong S1B C Number of melanoblasts significantly higher than Ednrb-/- at each stage.
Specimen S1B E12.0 Ednrb-/-: embryonic day 12.0; Ednrbtm1Myks/Ednrbtm1Myks (more )
Structure Cell Type Level Pattern Image Note
TS20: mesenchyme derived from neural crest melanoblast Weak S1B D Expression in melanoblasts reduced compared to wild type.
Specimen S1B E12.5 WT: embryonic day 12.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: mesenchyme derived from neural crest melanoblast Strong S1B E Number of melanoblasts significantly higher than Ednrb-/- at each stage.
Specimen S1B E12.5 Ednrb-/-: embryonic day 12.5; Ednrbtm1Myks/Ednrbtm1Myks (more )
Structure Cell Type Level Pattern Image Note
TS20: mesenchyme derived from neural crest melanoblast Weak S1B F Expression in melanoblasts reduced compared to wild type.
Specimen 6F WT left: embryonic day 12.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: mesenchyme derived from neural crest melanoblast Present 6F WT left-middle , 6F WT left
Specimen 6F Ednrb-/- left: embryonic day 12.5; Ednrbtm1Myks/Ednrbtm1Myks (more )
Structure Cell Type Level Pattern Image Note
TS20: mesenchyme derived from neural crest melanoblast Weak 6F Ednrb-/- left , 6F Ednrb-/- left-middle
Specimen 6F Ednrb-/-;Aim2-/- left: embryonic day 12.5; Aim2em2.1Gpt/Aim2em2.1Gpt, Ednrbtm1Myks/Ednrbtm1Myks (more )
Structure Level Pattern Image Note
TS20: mesenchyme derived from neural crest Strong 6F Ednrb-/-:Aim2-/- left , 6F Ednrb-/-:Aim2-/- left-middle Number of melanoblasts significantly higher than Ednrb-/- at each stage.
Specimen 6F WT right: embryonic day 12.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: tail mesenchyme derived from neural crest melanoblast Present 6F WT middle-right , 6F WT right
Specimen 6F Ednrb-/- right: embryonic day 12.5; Ednrbtm1Myks/Ednrbtm1Myks (more )
Structure Cell Type Level Pattern Image Note
TS20: tail mesenchyme derived from neural crest melanoblast Weak 6F Ednrb-/- middle-right , 6F Ednrb-/- right
Specimen 6F Ednrb-/-;Aim2-/- right: embryonic day 12.5; Aim2em2.1Gpt/Aim2em2.1Gpt, Ednrbtm1Myks/Ednrbtm1Myks (more )
Structure Level Pattern Image Note
TS20: tail mesenchyme derived from neural crest Strong 6F Ednrb-/-:Aim2-/- middle-right , 6F Ednrb-/-:Aim2-/- right Number of melanoblasts significantly higher than Ednrb-/- at each stage.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory