Aim2^em2.1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Aim2^em2.1Gpt
• Name: absent in melanoma 2; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
• MGI ID: MGI:7861656
• Gene: Aim2 Location: Chr1:173178445-173293606 bp, + strand Genetic Position: Chr1, 80.33 cM
• Alliance: Aim2^em2.1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: CRISPR-targeting introduced an loxP- and Lox2272-flanked EGFP-stop sequence. Cre-mediated recombination resulted in EGFP expression and premature transcription termination of the coding sequence. (J:359864)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:

11 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aim2 Mutation: 36 strains or lines available

References

• Original: J:359864 Chen Y, et al., The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast proliferation during early development. Development. 2024 Nov 15;151(22):dev202444
• All: 1 reference(s)