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Gene Expression Data
Assay Details
Assay
Reference: J:216503 Ka M, et al., MACF1 regulates the migration of pyramidal neurons via microtubule dynamics and GSK-3 signaling. Dev Biol. 2014 Nov 1;395(1):4-18
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7858948
Gene symbol: Tbr1
Gene name: T-box brain transcription factor 1
Antibody: anti-Tbr1
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 3C MACF1loxP/+; Nex-cre: postnatal day 10; Macf1tm1Efu/Macf1+, Neurod6tm1(cre)Kan/Neurod6+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cerebral cortex cerebral cortex neuron Present Regionally restricted 3C bottom left , 3C top left Immunopositive neurons were relatively accumulated in deeper layer neurons of the control cerebral cortex.
Specimen 3C MACF1loxP/loxP; Nex-cre: postnatal day 10; Macf1tm1Efu/Macf1tm1Efu, Neurod6tm1(cre)Kan/Neurod6+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cerebral cortex cerebral cortex neuron Present Regionally restricted 3C top right , 3C bottom right The distinct localization pattern of immunopositive neurons was not seen in MACF1<loxP/loxP>;Nex-cre cerebral cortex. Immunopositive neurons in MACF1<loxP/loxP>;Nex-cre mice were spread out evenly throughout the cortical bins compared to controls. Immunopositive neurons appeared abnormally spaced in the mutant compared with control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory