Gene Expression Data
Assay Details
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Assay
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Reference:
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J:262482
Dubos A, et al., A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations. Hum Mol Genet. 2018 Jun 15;27(12):2138-2153
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:7855767
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Gene symbol:
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Chat
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Gene name:
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choline O-acetyltransferase
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Antibody:
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anti-ChAT (AB144P)
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Detection system:
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Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
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Results
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Specimen
not shown Arxwt/0 P0:
postnatal day 0
(more  )
Specimen
not shown Arx P0:
(close  )
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Genetic Background:
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involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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Age:
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postnatal day 0
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Sex:
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Male
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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Specimen
not shown Arxdup24/0 P0:
postnatal day 0; Arxtm1.1Ics/Y
(more )
Specimen
not shown Arx P0:
(close )
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Genetic Background:
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involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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Mutant Allele(s):
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Arxtm1.1Ics/Y
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Age:
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postnatal day 0
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Sex:
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Male
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS27: corpus striatum |
neuron |
Present |
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The number of positive cells in this structure had decreased 22.8% compared to wild-type.
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Specimen
not shown Arxwt/0:
postnatal adult
(more )
Specimen
not shown Arx:
(close )
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Genetic Background:
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involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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Age:
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postnatal adult
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Sex:
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Male
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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Specimen
not shown Arxdup24/0:
postnatal adult; Arxtm1.1Ics/Y
(more )
Specimen
not shown Arx:
(close )
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Genetic Background:
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involves: 129S2/SvPas * C57BL/6J * C57BL/6N
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Mutant Allele(s):
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Arxtm1.1Ics/Y
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Age:
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postnatal adult
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Sex:
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Male
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS28: corpus striatum |
neuron |
Present |
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The number of positive cells in this structure had decreased 27.7% compared to wild-type.
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Analysis Tools
