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Gene Expression Data
Assay Details
Assay
Reference: J:294282 Li L, et al., The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. Cell Rep. 2019 Jul 16;28(3):698-711.e5
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7855694
Gene symbol: Eomes
Gene name: eomesodermin
Results
Specimen S2D Tbr2 Control: embryonic day 12.5; Tg(Dach1-cre)1Krs/0 (more )
Structure Cell Type Level Pattern Image Note
TS20: neocortex neural progenitor cell Present S2D Tbr2 Control , S2D Tbr2 Control lower Expression in intermediate progenitor cells.
Specimen S2D Tbr2 cKO: embryonic day 12.5; Ash2ltm1.1Bcgen/Ash2ltm1.1Bcgen, Tg(Dach1-cre)1Krs/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Present S2D Tbr2 cKO lower , S2D Tbr2 cKO Expression unaffected compared to control.
Specimen 3B Tbr2 Control: embryonic day 14.5; Tg(Dach1-cre)1Krs/0 (more )
Note: Double labeled: green - Eomes; red - EdU.
Structure Cell Type Level Pattern Image Note
TS22: neocortex neural progenitor cell Present 3B Control lower Tbr2 , 3B Control , 3B Control lower merged Expression in intermediate progenitor cells.
Specimen 3B Tbr2 cKO: embryonic day 14.5; Ash2ltm1.1Bcgen/Ash2ltm1.1Bcgen, Tg(Dach1-cre)1Krs/0 (more )
Note: Conditional mutant. Double labeled: green - Eomes; red - EdU.
Structure Level Pattern Image Note
TS22: neocortex Weak 3B cKO lower , 3B cKO lower merged , 3B cKO Expression significantly reduced compared to control.
Specimen 3D Tbr2 Control: embryonic day 16.5; Tg(Dach1-cre)1Krs/0 (more )
Structure Cell Type Level Pattern Image Note
TS24: neocortex neural progenitor cell Present 3D Tbr2 Control lower , 3D Tbr2 Control Expression in progenitor cells.
Specimen 3D Tbr2 cKO: embryonic day 16.5; Ash2ltm1.1Bcgen/Ash2ltm1.1Bcgen, Tg(Dach1-cre)1Krs/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: neocortex Weak 3D Tbr2 cKO , 3D Tbr2 cKO lower Expression significantly reduced compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory