About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:174095 Cai Z, et al., Loss of shp2-mediated mitogen-activated protein kinase signaling in muller glial cells results in retinal degeneration. Mol Cell Biol. 2011 Jul;31(14):2973-83
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7788476
Gene symbol: Ptpn11
Gene name: protein tyrosine phosphatase, non-receptor type 11
Results
Specimen 3B WT: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present Widespread 3B WT
TS28: retina inner nuclear layer Present Widespread 3B WT
TS28: retina inner plexiform layer Present Widespread 3B WT
TS28: retina outer nuclear layer Trace 3B WT Almost absent.
Specimen 3B cKO: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina layer Absent 3B cKO Absent in all layers.
Specimen 6H: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present 6H
TS28: retina inner nuclear layer Present 6H
TS28: retina inner plexiform layer Present 6H
TS28: retina outer nuclear layer Trace 6H Almost absent.
Specimen 6I: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina layer Absent 6I Absent in all layers.
Specimen 6J: postnatal day 21; Krastm4Tyj/Krastm4Tyj, Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina layer Absent 6J Absent in all layers.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory