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Gene Expression Data
Assay Details
Assay
Reference: J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
Assay type: RNA in situ
MGI Accession ID: MGI:7788198
Gene symbol: Tbx3
Gene name: T-box 3
Probe: Tbx3 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: otic placode Absent 1A right
Specimen 1B E9.5: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted 1B Tbx3 E9.5 Expression started at E9.5 in the lateral otocyst.
Specimen 1B E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 1B Tbx3 E10.5 From E10.5 onwards, expression was confined to the lateral aspects of the developing vestibular system and ventro-medially to the epithelium of the cochlear duct.
Specimen 1B E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: otocyst Present Regionally restricted 1B Tbx3 E11.5 Expression was detected ventro-medially in the epithelium of the cochlear duct.
TS19: inner ear vestibular component Present Regionally restricted 1B Tbx3 E11.5 Expression was detected in the lateral aspects of the developing vestibular system.
Specimen 1B E12.0: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: cochlear duct epithelium Present Regionally restricted 1B Tbx3 E12.0 Expression was detected ventro-medially in the epithelium of the cochlear duct.
TS20: inner ear vestibular component Present Regionally restricted 1B Tbx3 E12.0 Expression was detected in the lateral aspects of the developing vestibular system.
Specimen S6B anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S6B anterior control Tbx3
Specimen S6B anterior Tbx1KO: embryonic day 10.5; Tbx1tm1Pa/Tbx1tm1Pa (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6B anterior Tbx1KO Tbx3 Expression was lost in the posterior-medial region of the Tbx1KO otocyst.
Specimen S6B mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S6B mid-transverse control Tbx3
Specimen S6B mid-transverse Tbx1KO: embryonic day 10.5; Tbx1tm1Pa/Tbx1tm1Pa (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6B mid-transverse Tbx1KO Tbx3 Expression was lost in the posterior-medial region of the Tbx1KO otocyst.
Specimen S6B posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S6B posterior control Tbx3
Specimen S6B posterior Tbx1KO: embryonic day 10.5; Tbx1tm1Pa/Tbx1tm1Pa (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6B posterior Tbx1KO Tbx3 Expression was lost in the posterior-medial region of the Tbx1KO otocyst.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory