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Gene Expression Data
Assay Details
Assay
Reference: J:171630 Bagheri-Fam S, et al., Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome. Hum Mol Genet. 2011 Jun 1;20(11):2213-24
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7751464
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175; #9661)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 4A Control: embryonic day 15.5; Atrxtm1Rjg/Y (more )
Note: Quantified in Fig 4B. Double labeled: green - Casp3; red - Amh (assay MGI:7751458).
Structure Cell Type Level Pattern Image Note
TS23: Sertoli cell Sertoli cell Trace 4A left
Specimen 4A cKO: embryonic day 15.5; Atrxtm1Rjg/Y, Plekha5Tg(AMH-cre)1Flor/0 (more )
Note: Conditional mutant. Quantified in Fig 4B. Double labeled: green - Casp3; red - Amh (assay MGI:7751458).
Structure Cell Type Level Pattern Image Note
TS23: Sertoli cell Sertoli cell Present 4A right Marked increase (8-fold) in the number of positive Sertoli cells when compared with littermate controls.
Specimen not shown: embryonic day 17.5; Atrxtm1Rjg/Y (more )
Note: Quantified in Fig 4B.
Structure Cell Type Level Pattern Image Note
TS25: Sertoli cell Sertoli cell Trace
Specimen not shown: embryonic day 17.5; Atrxtm1Rjg/Y, Plekha5Tg(AMH-cre)1Flor/0 (more )
Note: Conditional mutant. Quantified in Fig 4B.
Structure Cell Type Level Pattern Image Note
TS25: Sertoli cell Sertoli cell Present Marked increase (40-fold) in the number of positive Sertoli cells when compared with littermate controls.
Specimen not shown: postnatal day 70; Atrxtm1Rjg/Y (more )
Note: Quantified in Fig 4B.
Structure Cell Type Level Pattern Image Note
TS28: Sertoli cell Sertoli cell Trace
Specimen not shown: postnatal day 70; Atrxtm1Rjg/Y, Plekha5Tg(AMH-cre)1Flor/0 (more )
Note: Conditional mutant. Quantified in Fig 4B.
Structure Cell Type Level Pattern Image Note
TS28: Sertoli cell Sertoli cell Trace Similar as in the control.
Specimen S4 Control: embryonic day 17.5; Atrxtm1Rjg/Y (more )
Structure Level Pattern Image Note
TS25: testis Trace S4_upper left
Specimen S4 cKO: embryonic day 17.5; Atrxtm1Rjg/Y, Plekha5Tg(AMH-cre)1Flor/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: testis Present S4_upper right Increased apoptosis in the mutant. No premature maturation of Sertoli cells (Gata1) were seen.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory