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Gene Expression Data
Assay Details
Assay
Reference: J:235368 Gomez-Del Arco P, et al., The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Cell Metab. 2016 May 10;23(5):881-92
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7738706
Gene symbol: Chd4
Gene name: chromodomain helicase DNA binding protein 4
Antibody: Anti-Chd4
Results
Specimen 2C WT: postnatal week 8 (more )
Structure Cell Type Level Pattern Image Note
TS28: cardiac muscle tissue cardiac muscle cell Present 2C IHC - WT

Specimen 2C Chd4corin: postnatal week 8; Chd4tm1.1Kge/Chd4tm1.1Kge, Corintm2(cre)Bamo/Corintm2(cre)Bamo (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cardiac muscle tissue cardiac muscle cell Ambiguous Regionally restricted 2C IHC - Chd4corin Chd4 was deleted in terminally differentiated cardiomyocytes by crossing Chd4<floxed> mice with the Corin-Cre postnatal driver line.

Specimen S1 WT: embryonic day 9.5 (more )
Note: Double labeled: red - Chd4; green - Tpm.
Structure Level Pattern Image Note
TS15: primitive ventricle cardiac muscle Present Regionally restricted S1A Chd4/Tpm WT Expression was detected in the left ventricle.
TS15: primitive ventricle endocardial lining Present Regionally restricted S1A Chd4/Tpm WT Expression was detected in the left ventricle.
TS15: visceral pericardium Present Regionally restricted S1A Chd4/Tpm WT Expression was detected in the left ventricle.

Specimen S1 Chd4nkx: embryonic day 9.5; Chd4tm1.1Kge/Chd4tm1.1Kge, Nkx2-5tm2(cre)Rph/Nkx2-5+ (more )
Note: Conditional mutant. Double labeled: red - Chd4; green - Tpm.
Structure Level Pattern Image Note
TS15: primitive ventricle endocardial lining Present Regionally restricted S1A Chd4/Tpm Chd4nkx Expression was detected in the left ventricle.
TS15: visceral pericardium Present Regionally restricted S1A Chd4/Tpm Chd4nkx Expression was detected in the left ventricle.
TS15: primitive ventricle cardiac muscle Absent S1A Chd4/Tpm Chd4nkx

Specimen S2D WT: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: cardiac muscle tissue cardiac muscle cell Present S2D IHC WT

Specimen S2D Chd4myh6: postnatal day 21; Chd4tm1.1Kge/Chd4tm1.1Kge, Tg(Myh6-cre)2182Mds/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cardiac muscle tissue cardiac muscle cell Absent S2D IHC Chd4myh6 The mutant showed cardiomyocyte-specific ablation.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory