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Gene Expression Data
Assay Details
Assay
Reference: J:66266 Lewandoski M, et al., Fgf8 signalling from the AER is essential for normal limb development. Nat Genet. 2000 Dec;26(4):460-3
Assay type: RNA in situ
MGI Accession ID: MGI:7720844
Gene symbol: Fgf8
Gene name: fibroblast growth factor 8
Probe: Fgf8 probe
Probe preparation: RNA
Results
Specimen 1b: embryonic day 9.5; Fgf8tm1.3Mrt/Fgf8+, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant. 29 somites
Structure Level Pattern Image Note
TS15: hindlimb ridge ectoderm Present 1b Expression throughout apical ectodermal ridge.
Specimen 1c: embryonic day 9.5; Fgf8tm1.3Mrt/Fgf8tm1.4Mrt, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant. 29 somtes
Structure Level Pattern Image Note
TS15: hindlimb ridge ectoderm Absent 1c No expression at 26-29 somite stage, or at later stages.
Specimen 1d: embryonic day 9.5; Fgf8tm1.3Mrt/Fgf8+, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant. 23 somites
Structure Level Pattern Image Note
TS15: forelimb bud presumptive apical ectodermal ridge Present 1d
Specimen 1e: embryonic day 9.5; Fgf8tm1.3Mrt/Fgf8tm1.4Mrt, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant. 23 somites
Structure Level Pattern Image Note
TS15: forelimb bud presumptive apical ectodermal ridge Weak 1e Transient expression at progressively lower levels from 23-29 somites.
Specimen 1f: embryonic day 9.5; Fgf8tm1.3Mrt/Fgf8+, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant. 26 somites
Structure Level Pattern Image Note
TS15: 1st branchial arch Present 1f
TS15: forelimb bud presumptive apical ectodermal ridge Present 1f
Specimen 1g: embryonic day 9.5; Fgf8tm1.3Mrt/Fgf8tm1.4Mrt, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant. 26 somites
Structure Level Pattern Image Note
TS15: 1st branchial arch Present 1g
TS15: forelimb bud presumptive apical ectodermal ridge Trace 1g Transient expression at progressively lower levels from 23-29 somites.
Specimen 1h: embryonic day 9.5; Fgf8tm1.3Mrt/Fgf8+, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant. 29 somites
Structure Level Pattern Image Note
TS15: forelimb bud presumptive apical ectodermal ridge Present 1h
Specimen 1i: embryonic day 9.5; Fgf8tm1.3Mrt/Fgf8tm1.4Mrt, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant. 29 somites
Structure Level Pattern Image Note
TS15: forelimb bud presumptive apical ectodermal ridge Trace 1i
Specimen 1j: embryonic day 10.0; Fgf8tm1.3Mrt/Fgf8+, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant. 33 somites
Structure Level Pattern Image Note
TS16: forelimb bud apical ectodermal ridge Present 1j
Specimen 1k: embryonic day 10.0; Fgf8tm1.3Mrt/Fgf8tm1.4Mrt, Tg(Msx2-cre)5Rem/0 (more )
Note: Conditional mutant. 33 somites
Structure Level Pattern Image Note
TS16: forelimb bud apical ectodermal ridge Absent 1k No expression at 33 somites or at later stages.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/28/2026
MGI 6.24 		The Jackson Laboratory