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Gene Expression Data
Assay Details
Assay
Reference: J:306217 Lee H, et al., Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development. BMB Rep. 2020 Jul;53(7):367-372
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7719989
Gene symbol: Arl13b
Gene name: ADP-ribosylation factor-like 13B
Antibody: anti-ARL13B
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 3E WT upper: embryonic day 14.5 (more )
Note: Double labeled: green - Arl13b; red - Tubg1 (assay MGI:7719991) and Tubg2 (assay MGI:7720051).
Structure Cell Type Level Pattern Image Note
TS22: lung epithelium lung multiciliated epithelial cell Present 3E WT upper Expressed in the primary cilia.
Specimen 3E KO upper: embryonic day 14.5; Cdk20tm1.1Jegg/Cdk20tm1.1Jegg (more )
Note: Double labeled: green - Arl13b; red - Tubg1 (assay MGI:7719991) and Tubg2 (assay MGI:7720051).
Structure Cell Type Level Pattern Image Note
TS22: lung epithelium lung multiciliated epithelial cell Present 3E KO upper Displayed swelling at their distal tips and shortened ciliary length compared with those in wild-type embryonic lungs. Decreased ciliary frequency compared with the wild-type.
Specimen 3E WT lower: embryonic day 14.5 (more )
Note: Double labeled: green - Arl13b; red - Tubg1 (assay MGI:7719991) and Tubg2 (assay MGI:7720051).
Structure Cell Type Level Pattern Image Note
TS22: lung mesenchyme lung multiciliated epithelial cell Present 3E WT lower Expressed in the primary cilia.
Specimen 3E KO lower: embryonic day 14.5; Cdk20tm1.1Jegg/Cdk20tm1.1Jegg (more )
Note: Double labeled: green - Arl13b; red - Tubg1 (assay MGI:7719991) and Tubg2 (assay MGI:7720051).
Structure Cell Type Level Pattern Image Note
TS22: lung mesenchyme lung multiciliated epithelial cell Present 3E KO lower Displayed swelling at their distal tips and shortened ciliary length compared with those in wild-type embryonic lungs. Decreased ciliary frequency compared with the wild-type.
Specimen S3A: embryonic day 17.5 (more )
Note: Double labeled: green - Arl13b; red - acetylated alpha tubulin.
Structure Cell Type Level Pattern Image Note
TS25: lung epithelium multiciliated columnar cell of tracheobronchial tree Present S3A
Specimen S3B: embryonic day 17.5; Cdk20tm1.1Jegg/Cdk20tm1.1Jegg (more )
Note: Double labeled: green - Arl13b; red - acetylated alpha tubulin.
Structure Cell Type Level Pattern Image Note
TS25: lung epithelium multiciliated columnar cell of tracheobronchial tree Present S3B Impaired motile multi-cilia formation was seen.
Specimen S3C: embryonic day 17.5 (more )
Note: Double labeled: green - Arl13b; red - Tubb4a (assay MGI:7720045).
Structure Cell Type Level Pattern Image Note
TS25: lung epithelium multiciliated columnar cell of tracheobronchial tree Present S3C
Specimen S3D: embryonic day 17.5; Cdk20tm1.1Jegg/Cdk20tm1.1Jegg (more )
Note: Double labeled: green - Arl13b; red - Tubb4a (assay MGI:7720045).
Structure Cell Type Level Pattern Image Note
TS25: lung epithelium multiciliated columnar cell of tracheobronchial tree Present S3D Impaired motile multi-cilia formation was seen.
Specimen S3E: embryonic day 17.5 (more )
Note: Double labeled: green - Arl13b; red - Tubg1 (assay MGI:7719991) and Tubg2 (assay MGI:7720051).
Structure Cell Type Level Pattern Image Note
TS25: lung epithelium multiciliated columnar cell of tracheobronchial tree Present S3E
Specimen S3F: embryonic day 17.5; Cdk20tm1.1Jegg/Cdk20tm1.1Jegg (more )
Note: Double labeled: green - Arl13b; red - Tubg1 (assay MGI:7719991) and Tubg2 (assay MGI:7720051).
Structure Cell Type Level Pattern Image Note
TS25: lung epithelium multiciliated columnar cell of tracheobronchial tree Present S3F Impaired motile multi-cilia formation was seen.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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