About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:279388 Weiss AC, et al., Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme. J Pathol. 2019 Aug;248(4):452-463
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7717887
Gene symbol: Gata2
Gene name: GATA binding protein 2
Antibody: Anti-Gata2
Results
Specimen 1C E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS20: ureteral mesenchyme Strong Uniform 1C E11.5 The protein was confined to the nucleus.
TS20: epithelial layer of ureter Weak 1C E11.5 The protein was confined to the nucleus.
Specimen 1C E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: ureteral mesenchyme Strong Uniform 1C E12.5 The protein was confined to the nucleus.
TS20: epithelial layer of ureter Weak 1C E12.5 The protein was confined to the nucleus.
Specimen 1C E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: ureteral mesenchyme Strong Regionally restricted 1C E14.5 Strong expression was detected in the inner region. The protein was confined to the nucleus.
TS22: urothelium of ureter Weak 1C E14.5 The protein was confined to the nucleus.
Specimen 1C E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: ureteral mesenchyme Weak Regionally restricted 1C E16.5 Expression continued in the inner region at reduced levels compared with E14.5. The protein was confined to the nucleus.
TS24: urothelium of ureter Weak 1C E16.5 The protein was confined to the nucleus.
Specimen 1C E18.5: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: ureteral mesenchyme Weak Regionally restricted 1C E18.5 Expression continued in the inner region at reduced levels compared with E14.5. The protein was confined to the nucleus.
TS26: urothelium of ureter umbrella cell of urothelium Present 1C E18.5 The protein was confined to the nucleus.
Specimen S1B E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: urothelium of primitive bladder Ambiguous S1B E12.5 bottom , S1B E12.5 top
Specimen S1B E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: urothelium of bladder Ambiguous S1B E14.5 top , S1B E14.5 bottom
Specimen S1B E16.5: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: urothelium of bladder umbrella cell of urothelium Present S1B E16.5 bottom , S1B E16.5 top
Specimen S1B E18.5: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: urothelium of bladder umbrella cell of urothelium Present S1B E18.5 bottom , S1B E18.5 top
Specimen S2 E12.5 control: embryonic day 12.5; Gata2tm1Sac/? (more )
Note: Littermates without the Tbx18cre were used as control.
Structure Level Pattern Image Note
TS20: ureteral mesenchyme Present S2_E12.5 control
Specimen S2 E12.5 Gata2cKO: embryonic day 12.5; Gata2tm1Sac/Gata2tm1Sac, Tbx18tm4(cre)Akis/Tbx18+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: ureteral mesenchyme Trace S2_E12.5 Gata2cKO Tissue-specific inactivation of Gata2 was confirmed by severe downregulation of expression in the ureteric mesenchyme of Tbx18<cre/+>;Gata2<fl/fl> (Gata2cKO) embryos.
Specimen S2 E13.5 control: embryonic day 13.5; Gata2tm1Sac/? (more )
Note: Littermates without the Tbx18cre were used as control.
Structure Level Pattern Image Note
TS21: ureteral mesenchyme Present S2_E13.5 control
Specimen S2 E13.5 Gata2cKO: embryonic day 13.5; Gata2tm1Sac/Gata2tm1Sac, Tbx18tm4(cre)Akis/Tbx18+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: ureteral mesenchyme Trace S2_E13.5 Gata2cKO Tissue-specific inactivation of Gata2 was confirmed by severe downregulation of expression in the ureteric mesenchyme of Tbx18<cre/+>;Gata2<fl/fl> (Gata2cKO) embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory