About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:350071 Aaron KA, et al., Selection of viral capsids and promoters affects the efficacy of rescue of Tmprss3-deficient cochlea. Mol Ther Methods Clin Dev. 2023 Sep 14;30:413-428
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7717818
Gene symbol: Myo7a
Gene name: myosin VIIA
Antibody: anti-Myo7a
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen S1K: postnatal day 13.5; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: red - Myo7a; blue - Sox2 (assay MGI:7717780); green - Tubb3 (assay MGI:7717819).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present S1K Similar as in the wild-type.
TS28: organ of Corti cochlear outer hair cell Present S1K Similar as in the wild-type.

Specimen S1L: postnatal day 13.5; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: red - Myo7a; blue - Sox2 (assay MGI:7717780); green - Tubb3 (assay MGI:7717819).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present S1L Similar as in the wild-type.
TS28: organ of Corti cochlear outer hair cell Present S1L Similar as in the wild-type.

Specimen S1M: postnatal day 14; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: red - Myo7a; blue - Sox2 (assay MGI:7717780); green - Tubb3 (assay MGI:7717819).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present S1M Pyknotic nuclei were seen.
TS28: organ of Corti cochlear outer hair cell Present S1M Pyknotic nuclei were seen.

Specimen S1N: postnatal day 14; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: red - Myo7a; blue - Sox2 (assay MGI:7717780); green - Tubb3 (assay MGI:7717819).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present S1N
TS28: organ of Corti cochlear outer hair cell Present S1N

Specimen S1O: postnatal day 14.5; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: red - Myo7a; blue - Sox2 (assay MGI:7717780); green - Tubb3 (assay MGI:7717819).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Trace S1O Hair cells were lost because of rapid and extensive degeneration.
TS28: organ of Corti cochlear outer hair cell Trace S1O Hair cells were lost because of rapid and extensive degeneration.

Specimen S1P: postnatal day 14.5; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: red - Myo7a; blue - Sox2 (assay MGI:7717780); green - Tubb3 (assay MGI:7717819).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Trace S1P Hair cells were lost.
TS28: organ of Corti cochlear outer hair cell Trace S1P Hair cells were lost.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory