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Gene Expression Data
Assay Details
Assay
Reference: J:350071 Aaron KA, et al., Selection of viral capsids and promoters affects the efficacy of rescue of Tmprss3-deficient cochlea. Mol Ther Methods Clin Dev. 2023 Sep 14;30:413-428
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7717780
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 1O: postnatal day 21 (more )
Note: Double labeled: blue - Sox2; red - Tubb3 (assay MGI:7717781).
Structure Cell Type Level Pattern Image Note
TS28: cochlea glial cell Present 1O
Specimen 1P: postnatal day 21; Tmprss3tm1Lex/Tmprss3+ (more )
Note: Double labeled: blue - Sox2; red - Tubb3 (assay MGI:7717781).
Structure Cell Type Level Pattern Image Note
TS28: cochlea glial cell Present 1P Similar as in the wild-type.
Specimen 1Q: postnatal day 21; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Double labeled: blue - Sox2; red - Tubb3 (assay MGI:7717781).
Structure Cell Type Level Pattern Image Note
TS28: cochlea glial cell Present 1Q Similar as in the wild-type.
Specimen 1R: postnatal day 120 (more )
Note: Double labeled: blue - Sox2; red - Tubb3 (assay MGI:7717781).
Structure Cell Type Level Pattern Image Note
TS28: cochlea glial cell Present 1R
Specimen 1S: postnatal day 120; Tmprss3tm1Lex/Tmprss3+ (more )
Note: Double labeled: blue - Sox2; red - Tubb3 (assay MGI:7717781).
Structure Cell Type Level Pattern Image Note
TS28: cochlea glial cell Present 1S Similar as in the wild-type.
Specimen 1T: postnatal day 120; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Double labeled: blue - Sox2; red - Tubb3 (assay MGI:7717781).
Structure Cell Type Level Pattern Image Note
TS28: cochlea glial cell Present 1T Similar as in the wild-type.
Specimen S1E: postnatal day 1 (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717773); red - Tmprss3 (assay MGI:7717800).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti organ of Corti supporting cell Present S1E
Specimen S1F: postnatal day 1; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717773); red - Tmprss3 (assay MGI:7717800).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti organ of Corti supporting cell Present S1F Similar as in the wild-type.
Specimen S1G: postnatal day 1 (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717773); red - Tmprss3 (assay MGI:7717800).
Structure Level Pattern Image Note
TS27: osseus spiral lamina Present S1G Rosenthal''s canal
Specimen S1H: postnatal day 1; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717773); red - Tmprss3 (assay MGI:7717800).
Structure Level Pattern Image Note
TS27: osseus spiral lamina Present S1H Similar as in the wild-type.
Specimen S1I: postnatal day 1 (more )
Note: Triple labeled: blue - Sox2 protein; green - Myo7a (assay MGI:7717773); red - Sox2 mRNA (assay MGI:7717788).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti organ of Corti supporting cell Present S1I
Specimen S1J: postnatal day 1 (more )
Note: Double labeled: blue - Sox2; green - Myo7a (assay MGI:7717773).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti organ of Corti supporting cell Present S1J
Specimen S1K: postnatal day 13.5; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717818); red - Tubb3 (assay MGI:7717819).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S1K Similar as in the wild-type.
Specimen S1L: postnatal day 13.5; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717818); red - Tubb3 (assay MGI:7717819).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S1L Similar as in the wild-type.
Specimen S1M: postnatal day 14; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717818); red - Tubb3 (assay MGI:7717819).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S1M Similar as in the wild-type.
Specimen S1N: postnatal day 14; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717818); red - Tubb3 (assay MGI:7717819).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S1N Similar as in the wild-type.
Specimen S1O: postnatal day 14.5; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717818); red - Tubb3 (assay MGI:7717819).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S1O Disorganized supporting cells were seen.
Specimen S1P: postnatal day 14.5; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717818); red - Tubb3 (assay MGI:7717819).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S1P Disorganized supporting cells were seen.
Specimen S6A: postnatal day 7 (more )
Note: Double labeled: blue - Sox2; green - Myo7a (assay MGI:7717773).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S6A
Specimen S6B: postnatal day 7 (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717773); red - Ppib (assay MGI:7717829).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S6B
Specimen S6C: postnatal day 7 (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717773); red - Tmprss3 (assay MGI:7717800).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S6C
Specimen S6E: postnatal day 6 (more )
Note: Double labeled: blue - Sox2; green - Myo7a (assay MGI:7717773). DapB gene is expressed by the Bacillus subtilis strain SMY, a soil bacterium, and not in mammalian tissues.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S6E
Specimen S6F: postnatal day 6 (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717773); red - Ppib (assay MGI:7717829).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S6F
Specimen S6G: postnatal day 6 (more )
Note: Triple labeled: blue - Sox2; green - Myo7a (assay MGI:7717773); red - Tmprss3 (assay MGI:7717800).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti organ of Corti supporting cell Present S6G
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory