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Gene Expression Data
Assay Details
Assay
Reference: J:350071 Aaron KA, et al., Selection of viral capsids and promoters affects the efficacy of rescue of Tmprss3-deficient cochlea. Mol Ther Methods Clin Dev. 2023 Sep 14;30:413-428
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7717773
Gene symbol: Myo7a
Gene name: myosin VIIA
Antibody: anti-Myo7a
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1D: postnatal day 12 (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present 1D upper
TS28: organ of Corti cochlear outer hair cell Present 1D upper
Specimen 1E: postnatal day 12; Tmprss3tm1Lex/Tmprss3+ (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present 1E upper Similar as in the wild-type.
TS28: organ of Corti cochlear outer hair cell Present 1E upper Similar as in the wild-type.
Specimen 1F: postnatal day 12; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present 1F upper Similar as in the wild-type.
TS28: organ of Corti cochlear outer hair cell Present 1F upper Similar as in the wild-type.
Specimen 1G: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present 1G upper
TS28: organ of Corti cochlear outer hair cell Present 1G upper
Specimen 1H: postnatal day 21; Tmprss3tm1Lex/Tmprss3+ (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present 1H upper Similar as in the wild-type.
TS28: organ of Corti cochlear outer hair cell Present 1H upper Similar as in the wild-type.
Specimen 1I: postnatal day 21; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Trace 1I upper All positive hair cells had significantly degenerated.
TS28: organ of Corti cochlear outer hair cell Trace 1I upper All positive hair cells had significantly degenerated.
Specimen 1J: postnatal day 120 (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present 1J upper
TS28: organ of Corti cochlear outer hair cell Present 1J upper
Specimen 1K: postnatal day 120; Tmprss3tm1Lex/Tmprss3+ (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present 1K upper Similar as in the wild-type.
TS28: organ of Corti cochlear outer hair cell Present 1K upper Similar as in the wild-type.
Specimen 1L: postnatal day 120; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Trace 1L upper All positive hair cells had significantly degenerated.
TS28: organ of Corti cochlear outer hair cell Trace 1L upper All positive hair cells had significantly degenerated.
Specimen S1E: postnatal day 1 (more )
Note: Triple labeled: green - Myo7a; blue - Sox2 (assay MGI:7717780); red - Tmprss3 (assay MGI:7717800).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti cochlear inner hair cell Present S1E
TS27: organ of Corti cochlear outer hair cell Present S1E
Specimen S1F: postnatal day 1; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: green - Myo7a; blue - Sox2 (assay MGI:7717780); red - Tmprss3 (assay MGI:7717800).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti cochlear inner hair cell Present S1F Similar as in the wild-type.
TS27: organ of Corti cochlear outer hair cell Present S1F Similar as in the wild-type.
Specimen S1G: postnatal day 1 (more )
Note: Triple labeled: green - Myo7a; blue - Sox2 (assay MGI:7717780); red - Tmprss3 (assay MGI:7717800).
Structure Level Pattern Image Note
TS27: osseus spiral lamina Absent S1G Rosenthal''s canal
Specimen S1H: postnatal day 1; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Triple labeled: green - Myo7a; blue - Sox2 (assay MGI:7717780); red - Tmprss3 (assay MGI:7717800).
Structure Level Pattern Image Note
TS27: osseus spiral lamina Absent S1H Same as in the wild-type.
Specimen S1I: postnatal day 1 (more )
Note: Triple labeled: green - Myo7a; red - Sox2 mRNA (assay MGI:7717788); blue - Sox2 (assay MGI:7717780).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti cochlear inner hair cell Present S1I
TS27: organ of Corti cochlear outer hair cell Present S1I
Specimen S1J: postnatal day 1 (more )
Note: Double labeled: green - Myo7a; blue - Sox2 (assay MGI:7717780). DapB gene is expressed by the Bacillus subtilis strain SMY, a soil bacterium, and not in mammalian tissues.
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti cochlear inner hair cell Present S1J
TS27: organ of Corti cochlear outer hair cell Present S1J
Specimen S1Q: postnatal day 12; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Apex. Double labeled: green - Myo7a; blue - Sox2 (assay MGI:7717779).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present S1Q Similar as in the wild-type.
TS28: organ of Corti cochlear outer hair cell Present S1Q Similar as in the wild-type.
Specimen S1R: postnatal day 12; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Base. Double labeled: green - Myo7a; blue - Sox2 (assay MGI:7717779).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present S1R Similar as in the wild-type.
TS28: organ of Corti cochlear outer hair cell Present S1R Similar as in the wild-type.
Specimen S1S: postnatal day 21; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Apex. Double labeled: green - Myo7a; blue - Sox2 (assay MGI:7717779).
Structure Level Pattern Image Note
TS28: organ of Corti Trace S1S All positive hair cells had significantly degenerated.
Specimen S1T: postnatal day 21; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Base. Double labeled: green - Myo7a; blue - Sox2 (assay MGI:7717779).
Structure Level Pattern Image Note
TS28: organ of Corti Trace S1T All positive hair cells had significantly degenerated.
Specimen S1U: postnatal day 120; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Apex. Double labeled: green - Myo7a; blue - Sox2 (assay MGI:7717779).
Structure Level Pattern Image Note
TS28: organ of Corti Trace S1U All positive hair cells had significantly degenerated.
Specimen S1V: postnatal day 120; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Base. Double labeled: green - Myo7a; blue - Sox2 (assay MGI:7717779).
Structure Level Pattern Image Note
TS28: organ of Corti Trace S1V All positive hair cells had significantly degenerated.
Specimen S6A: postnatal day 7 (more )
Note: Double labeled: green - Myo7a; blue - Sox2 (assay MGI:7717780). DapB gene is expressed by the Bacillus subtilis strain SMY, a soil bacterium, and not in mammalian tissues.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present S6A
TS28: organ of Corti cochlear outer hair cell Present S6A
Specimen S6B: postnatal day 7 (more )
Note: Triple labeled: green - Myo7a; red - Ppib (assay MGI:7717829); blue - Sox2 (assay MGI:7717780).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present S6B
TS28: organ of Corti cochlear outer hair cell Present S6B
Specimen S6C: postnatal day 7 (more )
Note: Triple labeled: green - Myo7a; blue - Sox2 (assay MGI:7717780); red - Tmprss3 (assay MGI:7717800).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present S6C
TS28: organ of Corti cochlear outer hair cell Present S6C
Specimen S6E: postnatal day 6 (more )
Note: Double labeled: green - Myo7a; blue - Sox2 (assay MGI:7717780). DapB gene is expressed by the Bacillus subtilis strain SMY, a soil bacterium, and not in mammalian tissues.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present S6E
TS28: organ of Corti cochlear outer hair cell Present S6E
Specimen S6F: postnatal day 6 (more )
Note: Triple labeled: green - Myo7a; blue - Ppib (assay MGI:7717829); red - Sox2 (assay MGI:7717780).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present S6F
TS28: organ of Corti cochlear outer hair cell Present S6F
Specimen S6G: postnatal day 6 (more )
Note: Triple labeled: green - Myo7a; blue - Sox2 (assay MGI:7717780); red - Tmprss3 (assay MGI:7717800).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present S6G
TS28: organ of Corti cochlear outer hair cell Present S6G
Specimen not shown: postnatal day 5 (more )
Note: Summarized in Table S1.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present
TS28: organ of Corti cochlear outer hair cell Present
Specimen not shown: postnatal day 5; Tmprss3tm1Lex/Tmprss3+ (more )
Note: Summarized in Table S1.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Similar as in the wild-type.
TS28: organ of Corti cochlear outer hair cell Present Similar as in the wild-type.
Specimen not shown: postnatal day 5; Tmprss3tm1Lex/Tmprss3tm1Lex (more )
Note: Summarized in Table S1.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Similar as in the wild-type.
TS28: organ of Corti cochlear outer hair cell Present Similar as in the wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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