| Assay |
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| Results |
(a) Values are listed as levels of the Col2a1 IIC isoform expressed as a percentage of the total copy number of IIA, IIB, IIC and IID in chondrocytes from wild type, ki/+ and ki/ki cartilage at each time point. Strength was assigned by curator as follows: >= 90% = strong; 10-89% = present; 1-9.9% = weak; 0.1-0.9% = trace; <0.09 = ambiguous; 0.00 = absent. (b) 1.33% (c) 0.77% (d) 0.00%. As expected, no isoform IIC mRNA was detected in E12.5 ki/ki chondrocytes at all time points, consistent with ablation of the IIC splice site. (e) 0.33% (f) 0.28% (g) 0.00%. As expected, no isoform IIC mRNA was detected in E16.5 ki/ki chondrocytes at all time points, consistent with ablation of the IIC splice site. (h) 0.11%. At P0, IIC levels were barely detectable or undetectable in wild type. (i) 0.08% (j) 0.00%. As expected, no isoform IIC mRNA was detected in P0 ki/ki chondrocytes at all time points, consistent with ablation of the IIC splice site. (k) 0.03%. At P7, IIC levels were barely detectable or undetectable in wild type. (l) 0.02% (m) 0.00%. As expected, no isoform IIC mRNA was detected in P7 ki/ki chondrocytes at all time points, consistent with ablation of the IIC splice site. (n) 0.01%. At P14, IIC levels were barely detectable or undetectable in wild type. (o) 0.01% (p) 0.00%. As expected, no isoform IIC mRNA was detected in P14 ki/ki chondrocytes at all time points, consistent with ablation of the IIC splice site. (q) 0.01%. At P28, IIC levels were barely detectable or undetectable in wild type. (r) 0.00%. As expected, no isoform IIC mRNA was detected in P28 ki/ki chondrocytes at all time points, consistent with ablation of the IIC splice site. (s) 0.06%. At P56, IIC levels were barely detectable or undetectable in wild type. (t) 0.03% (u) 0.00%. As expected, no isoform IIC mRNA was detected in P56 ki/ki chondrocytes at all time points, consistent with ablation of the IIC splice site. |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/30/2025 MGI 6.24 |
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