| Assay |
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| Results |
(a) Values are listed as levels of the Col2a1 IIA isoform expressed as a percentage of the total copy number of IIA, IIB, IIC and IID in chondrocytes from wild type, ki/+ and ki/ki cartilage at each time point. Strength was assigned by curator as follows: >= 90% = strong; 10-89% = present; 1-9.9% = weak; 0.1-0.9% = trace; <0.09 = ambiguous; 0.00 = absent. (b) 94.88%. IIA is the major isoform produced at E12.5. (c) 95.47% (d) 96.57%. The ki/ki mice had higher percentage of IIA compared with wild type. (e) 26.37%. By E16.5, the splicing switch from isoforms IIA/IID to IIB had occurred in wild type. (f) 42.61% (g) 50.04%. Increased percentage of IIA isoform in ki/ki mice was more apparent after E16.5. (h) 6.83% (i) 9.74% (j) 35.51%. The ki/ki mice had higher percentage of IIA compared with wild type. (k) 6.28% (l) 7.13% (m) 16.77%. The ki/ki mice had higher percentage of IIA compared with wild type. (n) 0.90% (o) 8.99% (p) 26.06%. The ki/ki mice had higher percentage of IIA compared with wild type. (q) 0.69% (r) 8.22% (s) 20.48%. The ki/ki mice had higher percentage of IIA compared with wild type. (t) 5.77% (u) 36.24% (v) 50.40%. The ki/ki mice had higher percentage of IIA compared with wild type. |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/30/2025 MGI 6.24 |
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