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Gene Expression Data
Assay Details
Assay
Reference: J:201463 Watson LA, et al., Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest. 2013 May 1;123(5):2049-63
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7705315
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved caspase-3 (Asp175)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1C Ctrl: embryonic day 13.5; Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Double labeled: green - Casp3; red - H2ax (assay MGI:7705273). Quantification was shown in the 1C right graphs.
Structure Level Pattern Image Note
TS21: cerebral cortex Present Single cells 1C Ctrl right , 1C Ctrl middle
Specimen 1C cKO: embryonic day 13.5; Atrxtm1Rjg/Y, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant. Double labeled: green - Casp3; red - H2ax (assay MGI:7705273). Quantification was shown in the 1C right graphs.
Structure Level Pattern Image Note
TS21: cerebral cortex Present 1C cKO middle , 1C cKO right Increased expression compared with the control.
Specimen not shown cKO;p53-/-: embryonic day 13.5; Atrxtm1Rjg/Y, Foxg1tm1(cre)Skm/Foxg1+, Trp53tm1Tyj/Trp53tm1Tyj (more )
Note: Conditional mutant. Double labeled: green - Casp3; red - H2ax (assay MGI:7705273). Quantification was shown in the 1C right graphs.
Structure Level Pattern Image Note
TS21: telencephalon Trace Apoptosis (i.e., cleaved caspase-3+ cells) was rare in the cortex, hippocampal hem (future hippocampus) and basal ganglia.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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