Gene Expression Data
Assay Details
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Assay
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Reference:
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J:346457
Gao X, et al., Nkx2.3 transcription factor is a key regulator of mucous cell identity in salivary glands. Dev Biol. 2024 May;509:1-10
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Assay type:
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In situ reporter (knock in)
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MGI Accession ID:
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MGI:7643756
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Gene symbol:
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Nkx2-3
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Gene name:
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NK2 homeobox 3
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Reporter:
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lacZ
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Direct Detection
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Results
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Specimen
not shown:
embryonic day 15.5; Nkx2-3tm1Rph/Nkx2-3 +
(more  )
Specimen
not shown:
(close  )
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Genetic Background:
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involves: 129S1/Sv * C57BL/6J
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Mutant Allele(s):
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Nkx2-3tm1Rph/Nkx2-3+
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Specimen
1B:
embryonic day 18.5; Nkx2-3tm1Rph/Nkx2-3 +
(more )
Specimen
1B:
(close )
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Genetic Background:
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involves: 129S1/Sv * C57BL/6J
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Mutant Allele(s):
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Nkx2-3tm1Rph/Nkx2-3+
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Specimen
1C:
(close )
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Genetic Background:
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involves: 129S1/Sv * C57BL/6J
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Mutant Allele(s):
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Nkx2-3tm1Rph/Nkx2-3tm1Rph
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: sublingual gland |
Present |
Regionally restricted |
1C
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The number of expressing cells is reduced in the mutant; the tissue has disrupted morphology and disorganized mucous acinar cells.
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Specimen
1D:
(close )
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Genetic Background:
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involves: 129S1/Sv * C57BL/6J
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Mutant Allele(s):
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Nkx2-3tm1Rph/Nkx2-3+
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Age:
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postnatal day 5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS28: sublingual gland |
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Present |
Regionally restricted |
1D
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Expression is seen in most proacinar cells, as well as some duct cells.
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| TS28: sublingual gland |
acinar cell of salivary gland |
Present |
Regionally restricted |
1D
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Expression is seen in most proacinar cells, as well as some duct cells.
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Specimen
1E:
(close )
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Genetic Background:
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involves: 129S1/Sv * C57BL/6J
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Mutant Allele(s):
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Nkx2-3tm1Rph/Nkx2-3tm1Rph
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Age:
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postnatal day 5
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: sublingual gland |
Present |
Regionally restricted |
1E
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The number of expressing cells is reduced in the mutant; the tissue has disrupted morphology and disorganized mucous acinar cells.
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Specimen
1F:
(close )
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Genetic Background:
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involves: 129S1/Sv * C57BL/6J
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Mutant Allele(s):
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Nkx2-3tm1Rph/Nkx2-3+
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Age:
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postnatal day 21
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS28: sublingual gland |
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Present |
Regionally restricted |
1F
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Expression is seen in most proacinar cells, as well as some duct cells.
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| TS28: sublingual gland |
acinar cell of salivary gland |
Present |
Regionally restricted |
1F
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Expression is seen in most proacinar cells, as well as some duct cells.
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Specimen
1G:
(close )
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Genetic Background:
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involves: 129S1/Sv * C57BL/6J
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Mutant Allele(s):
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Nkx2-3tm1Rph/Nkx2-3tm1Rph
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Age:
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postnatal day 21
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: sublingual gland |
Present |
Regionally restricted |
1G
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The number of expressing cells is reduced in the mutant; the tissue has disrupted morphology and disorganized mucous acinar cells.
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Analysis Tools
