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Gene Expression Data
Assay Details
Assay
Reference: J:35877 Xiang M, et al., Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11950-5
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7641434
Gene symbol: Pou4f1
Gene name: POU domain, class 4, transcription factor 1
Antibody: anti-Brn-3a
Results
Specimen 3A: embryonic day 20.0 (more )
Structure Level Pattern Image Note
TS26: dorsal root ganglion Present 3A
Specimen 3B: embryonic day 20.0; Pou4f1tm1Nat/Pou4f1tm1Nat (more )
Structure Level Pattern Image Note
TS26: dorsal root ganglion Absent 3B
Specimen 4G: embryonic day 20.0 (more )
Structure Level Pattern Image Note
TS26: trigeminal ganglion Present 4G
Specimen 4H: embryonic day 20.0; Pou4f1tm1Nat/Pou4f1tm1Nat (more )
Structure Level Pattern Image Note
TS26: trigeminal ganglion Absent 4H
Specimen 5A: embryonic day 20.0 (more )
Structure Level Pattern Image Note
TS26: retina ganglion cell layer Present 5A Expression only in ganglion cells.
Specimen 5B: embryonic day 20.0; Pou4f1tm1Nat/Pou4f1tm1Nat (more )
Structure Level Pattern Image Note
TS26: retina ganglion cell layer Absent 5B
Specimen 6A: embryonic day 20.0 (more )
Structure Cell Type Level Pattern Image Note
TS26: medial habenular nucleus neuron Present 6A Expression at high density in medial habenula. Expression in most neurons.
TS26: lateral habenular nucleus Present Scattered 6A Lower density of expression in lateral habenula. Expression in scattered neurons.
Specimen 6B: embryonic day 20.0; Pou4f1tm1Nat/Pou4f1tm1Nat (more )
Structure Level Pattern Image Note
TS26: lateral habenular nucleus Absent 6B
TS26: medial habenular nucleus Absent 6B
Specimen 7A: embryonic day 20.0 (more )
Structure Level Pattern Image Note
TS26: interpeduncular nucleus Present 7A
TS26: red nucleus Present 7A
TS26: superior colliculus Present 7A
TS26: periaqueductal grey Present Regionally restricted 7A Expression in dorsal central grey,
Specimen 7B: embryonic day 20.0; Pou4f1tm1Nat/Pou4f1tm1Nat (more )
Structure Level Pattern Image Note
TS26: interpeduncular nucleus Absent 7B
TS26: periaqueductal grey Absent 7B
TS26: red nucleus Absent 7B
TS26: superior colliculus Absent 7B
Specimen 8A: embryonic day 20.0 (more )
Structure Level Pattern Image Note
TS26: inferior olivary nucleus Present Widespread 8A Expression uniformly present in many neurons along entire rostro-caudal extent.
Specimen 8B: embryonic day 20.0; Pou4f1tm1Nat/Pou4f1tm1Nat (more )
Structure Level Pattern Image Note
TS26: inferior olivary nucleus Absent 8B
Specimen 8C: embryonic day 20.0 (more )
Structure Level Pattern Image Note
TS26: inferior olivary nucleus Present Widespread 8C Expression uniformly present in many neurons along entire rostro-caudal extent.
Specimen 8D: embryonic day 20.0; Pou4f1tm1Nat/Pou4f1tm1Nat (more )
Structure Level Pattern Image Note
TS26: inferior olivary nucleus Absent 8D
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory