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Gene Expression Data
Assay Details
Assay
Reference: J:347585 Leon NY, et al., Y chromosome damage underlies testicular abnormalities in ATR-X syndrome. iScience. 2024 May 17;27(5):109629
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7628671
Gene symbol: Atrx
Gene name: ATRX, chromatin remodeler
Antibody: anti-Atrx (H-300, sc-15408)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1A Control: embryonic day 16.5; Atrxtm1Rjg/Y (more )
Note: Double labeled: gray - Atrx; red - Gata4 (assay MGI:7628670).
Structure Cell Type Level Pattern Image Note
TS24: Sertoli cell Sertoli cell Present Regionally restricted 1A Control (merged) , 1A Control ATRX Diffuse nuclear expression and moderate levels at chromocenters containing highly compacted pericentromeric heterochromatin.
Specimen 1A ScAttrxKO: embryonic day 16.5; Atrxtm1Rjg/Y, Plekha5Tg(AMH-cre)1Flor/0 (more )
Note: Conditional mutant. Double labeled: green - Atrx; red - Gata4 (assay MGI:7628670).
Structure Cell Type Level Pattern Image Note
TS24: Sertoli cell Sertoli cell Present Regionally restricted 1A ScAtrxKO (merged) , 1A ScAtrxKO ATRX Diffuse nuclear expression and moderate levels at chromocenters containing highly compacted pericentromeric heterochromatin.
Specimen S1 Control: embryonic day 17.5; Atrxtm1Rjg/Y (more )
Note: Double labeled: green - Atrx; red - Gata4 (assay MGI:7628670).
Structure Cell Type Level Pattern Image Note
TS25: Sertoli cell Sertoli cell Present Regionally restricted S1_DAPI/GATA4/ATRX , S1_GATA/ATRX , S1_ATRX Strong Atrx expression in nuclear speckle co-localized with focus of Gata4 expression.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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