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Gene Expression Data
Assay Details
Assay
Reference: J:309183 Gomes AL, et al., RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis. Front Cell Dev Biol. 2020;8:711
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7610733
Gene symbol: Pcna
Gene name: proliferating cell nuclear antigen
Antibody: PC10
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 3G Ctrl: embryonic day 15.5; Rint1tm1.1Pof/Rint1tm1.1Pof (more )
Note: Double labeled: green - Pcna; red - TUNEL.
Structure Cell Type Level Pattern Image Note
TS23: retina layer retinal progenitor cell Present 3G Ctrl PCNA , 3G Ctrl merge
Specimen 3G cKO: embryonic day 15.5; Rint1tm1.1Pof/Rint1tm1.1Pof, Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Conditional mutant. Double labeled: green - Pcna; red - TUNEL.
Structure Cell Type Level Pattern Image Note
TS23: retina layer retinal progenitor cell Present 3G cKO PCNA , 3G cKO merge Approximately half of the TUNEL+ cells were PCNA+ in the mutant.
Specimen S2A Ctrl: embryonic day 15.5; Rint1tm1.1Pof/Rint1tm1.1Pof (more )
Structure Cell Type Level Pattern Image Note
TS23: retina layer retinal progenitor cell Present S2A Ctrl
Specimen S2A cKO: embryonic day 15.5; Rint1tm1.1Pof/Rint1tm1.1Pof, Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS23: retina layer retinal progenitor cell Present S2A cKO Similar as in the control (quantified in Fig S2B).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory