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Gene Expression Data
Assay Details
Assay
Reference: J:334252 Zapata G, et al., Generation of a mouse model of the neurodevelopmental disorder with dysmorphic facies and distal limb anomalies syndrome. Hum Mol Genet. 2022 Oct 10;31(20):3405-3421
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7595953
Gene symbol: Satb2
Gene name: special AT-rich sequence binding protein 2
Results
Specimen 4A Ctrl: postnatal day 2 (more )
Note: Triple labeled: green - Satb2; gray - Bcl11b (assay MGI:7595954); red - Tbr1 (assay MGI:7595955).
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted 4A Ctrl (merged) , 4A Ctrl Satb2 Expression in cortical layers II-V.
Specimen 4A cKO: postnatal day 2; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: green - Satb2; gray - Bcl11b (assay MGI:7595954); red - Tbr1 (assay MGI:7595955).
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted 4A cKO Satb2 , 4A cKO (merged)
Specimen 4B Ctrl: postnatal day 2 (more )
Note: Triple labeled: green - Satb2; gray - Bcl11b (assay MGI:7595954); red - Tbr1 (assay MGI:7595955).
Structure Level Pattern Image Note
TS27: cortical layer II Present 4B Ctrl Merge , 4B Ctrl Satb2
TS27: cortical layer III Present 4B Ctrl Merge , 4B Ctrl Satb2
TS27: cortical layer IV Present 4B Ctrl Merge , 4B Ctrl Satb2
TS27: cortical layer V Present 4B Ctrl Merge , 4B Ctrl Satb2
Specimen 4B cKO: postnatal day 2; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: green - Satb2; gray - Bcl11b (assay MGI:7595954); red - Tbr1 (assay MGI:7595955).
Structure Level Pattern Image Note
TS27: cortical layer II Present 4B cKO Satb2 , 4B cKO Merge Expressing cells present in layers II-III.
TS27: cortical layer III Present 4B cKO Satb2 , 4B cKO Merge Expressing cells present in layers II-III.
TS27: cortical layer V Weak 4B cKO Merge , 4B cKO Satb2 Fewer expressing cells in layer V.
TS27: neocortex Present Regionally restricted 4B cKO Merge , 4B cKO Satb2 Some expression cells located below layer VI.
Specimen 4C: postnatal day 2; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: green - Satb2; gray - Bcl11b (assay MGI:7595954); red - Tbr1 (assay MGI:7595955).
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted 4C Satb2-Ctip2 , 4C Satb2-Ctip2-Tbr1
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory