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Gene Expression Data
Assay Details
Assay
Reference: J:334252 Zapata G, et al., Generation of a mouse model of the neurodevelopmental disorder with dysmorphic facies and distal limb anomalies syndrome. Hum Mol Genet. 2022 Oct 10;31(20):3405-3421
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7595954
Gene symbol: Bcl11b
Gene name: B cell leukemia/lymphoma 11B
Results
Specimen 4A Ctrl: postnatal day 2 (more )
Note: Triple labeled: gray - Bcl11b; green - Satb2 (assay MGI:7595953); red - Tbr1 (assay MGI:7595955).
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted 4A Ctrl (merged) , 4A Ctrl Ctip2 Expression in cortical layer V.
Specimen 4A cKO: postnatal day 2; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: gray - Bcl11b; green - Satb2 (assay MGI:7595953); red - Tbr1 (assay MGI:7595955).
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted 4A cKO Ctip2 , 4A cKO (merged)
Specimen 4B Ctrl: postnatal day 2 (more )
Note: Triple labeled: gray - Bcl11b; green - Satb2 (assay MGI:7595953); red - Tbr1 (assay MGI:7595955).
Structure Level Pattern Image Note
TS27: cortical layer V Strong 4B Ctrl Ctip2 , 4B Ctrl Merge High expressing cells typically reside in layer V.
TS27: cortical layer VI Weak 4B Ctrl Ctip2 , 4B Ctrl Merge Low expressing cells co-localize with Tbr1 in layer VI.
TS27: cortical layer II Trace 4B Ctrl Ctip2 , 4B Ctrl Merge Very few expressing cells in layers II-III.
TS27: cortical layer III Trace 4B Ctrl Ctip2 , 4B Ctrl Merge Very few expressing cells in layers II-III.
Specimen 4B cKO: postnatal day 2; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: gray - Bcl11b; green - Satb2 (assay MGI:7595953); red - Tbr1 (assay MGI:7595955).
Structure Level Pattern Image Note
TS27: cortical layer V Weak 4B cKO Ctip2 , 4B cKO Merge 90% decrease in proportion of high-expressing cells in layer V.
TS27: cortical layer VI Weak 4B cKO Ctip2 , 4B cKO Merge 60% reduction in low-expressing cells in layer VI.
TS27: cortical layer II Trace 4B cKO Ctip2 , 4B cKO Merge 2.7-fold increased in proportion of low-expressing cells in layers II-III.
TS27: cortical layer III Trace 4B cKO Ctip2 , 4B cKO Merge 2.7-fold increased in proportion of low-expressing cells in layers II-III.
Specimen 4C: postnatal day 2; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Triple labeled: gray - Bcl11b; green - Satb2 (assay MGI:7595953); red - Tbr1 (assay MGI:7595955).
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted 4C Satb2-Ctip2 , 4C Satb2-Ctip2-Tbr1 , 4C Ctip2-Tbr1
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory