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Gene Expression Data
Assay Details
Assay
Reference: J:333825 Lorenzana-Carrillo MA, et al., TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure. Sci Transl Med. 2022 Nov 2;14(669):eabm3565
Assay type: Western blot
MGI Accession ID: MGI:7581054
Gene symbol: Pkm
Gene name: pyruvate kinase, muscle
Antibody: Phospho-PKM2 (Ser37) Antibody (PA5-105500)
Detection system: Secondary antibody coupled to horseradish peroxidase
Assay notes: The antibody used recognizes the phosphorylated form of the protein.
Results Image: S5C S37P-PKM2
 Sample Information Bands Other Sample Information
Lane AgeStructure Size Not Specified (b) Genetic BackgroundMutant Allele(s)Sex Note
Control Cre+ 1 E18.0 (a) TS26: heart Present Not Specified Tg(Myh6-cre)2182Mds/0Not Specified
Control Cre+ 2 E18.0 (a) TS26: heart Present Not Specified Tg(Myh6-cre)2182Mds/0Not Specified
Control Cre+ 3 E18.0 (a) TS26: heart Present Not Specified Tg(Myh6-cre)2182Mds/0Not Specified
Control Cre+ 4 E18.0 (a) TS26: heart Present Not Specified Tg(Myh6-cre)2182Mds/0Not Specified
Control Cre+ 5 E18.0 (a) TS26: heart Present Not Specified Tg(Myh6-cre)2182Mds/0Not Specified
Pkm2 Mut Cre+ 1 E18.0 (a) TS26: heart Present involves: 129S6/SvEvTac * FVB/N Pkmtm1.1Mgvh/Pkmtm1.1Mgvh, Tg(Myh6-cre)2182Mds/0Not Specified Conditional mutant.
Pkm2 Mut Cre+ 2 E18.0 (a) TS26: heart Present involves: 129S6/SvEvTac * FVB/N Pkmtm1.1Mgvh/Pkmtm1.1Mgvh, Tg(Myh6-cre)2182Mds/0Not Specified Conditional mutant.
Pkm2 Mut Cre+ 3 E18.0 (a) TS26: heart Present involves: 129S6/SvEvTac * FVB/N Pkmtm1.1Mgvh/Pkmtm1.1Mgvh, Tg(Myh6-cre)2182Mds/0Not Specified Conditional mutant.
Pkm2 Mut Cre+ 4 E18.0 (a) TS26: heart Present involves: 129S6/SvEvTac * FVB/N Pkmtm1.1Mgvh/Pkmtm1.1Mgvh, Tg(Myh6-cre)2182Mds/0Not Specified Conditional mutant.
Pkm2 Mut Cre+ 5 E18.0 (a) TS26: heart Present involves: 129S6/SvEvTac * FVB/N Pkmtm1.1Mgvh/Pkmtm1.1Mgvh, Tg(Myh6-cre)2182Mds/0Not Specified Conditional mutant.
Notes:
(a) Age of embryo at noon of plug day not specified in reference.
(b) Expression in the mutant was similar as in the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory