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Gene Expression Data
Assay Details
Assay
Reference: J:343078 Diniz F, et al., Acetyl-CoA is a key molecule for nephron progenitor cell pool maintenance. Nat Commun. 2023 Nov 25;14(1):7733
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7567406
Gene symbol: Six2
Gene name: sine oculis-related homeobox 2
Antibody: anti-Six2 (11562-1-AP)
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen 8a: postnatal day 0; Aclytm1.1Welk/Acly+ (more )
Note: Triple labeled: red - Six2; white - Wnt4 (assay MGI:7567407); green - DBA.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present 8a Expression in cap mesenchyme forming a crescent around ureteric bud.
Specimen 8b: postnatal day 0; Aclytm1.1Welk/Acly+, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Six2; white - Wnt4 (assay MGI:7567407); green - DBA.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present Regionally restricted 8b Expression affected in heterozygotes but to a lesser extent than for homozygotes.
Specimen 8c: postnatal day 0; Aclytm1.1Welk/Aclytm1.1Welk, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Six2; white - Wnt4 (assay MGI:7567407); green - DBA.
Structure Level Pattern Image Note
TS27: cap mesenchyme Weak 8c Authors report a reduction of expressing cells compared to wild type.
Specimen 8d: postnatal day 0; Aclytm1.1Welk/Acly+ (more )
Note: Triple labeled: red - Six2; white - Lhx1 (assay MGI:7567408); green - DBA.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present 8d Expression in cap mesenchyme forming a crescent around ureteric bud.
Specimen 8e: postnatal day 0; Aclytm1.1Welk/Acly+, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Six2; white - Lhx1 (assay MGI:7567408); green - DBA.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present Regionally restricted 8e Expression affected in heterozygotes but to a lesser extent than for homozygotes.
Specimen 8f: postnatal day 0; Aclytm1.1Welk/Aclytm1.1Welk, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Six2; white - Lhx1 (assay MGI:7567408); green - DBA.
Structure Level Pattern Image Note
TS27: cap mesenchyme Weak 8f Authors report a reduction of expressing cells compared to wild type.
Specimen 8g: embryonic day 16.5; Aclytm1.1Welk/Acly+ (more )
Note: Triple labeled: red - Six2; white - Wnt4 (assay MGI:7567407); green - cytokeratin.
Structure Level Pattern Image Note
TS24: cap mesenchyme Present 8g
Specimen 8h: embryonic day 16.5; Aclytm1.1Welk/Acly+, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Six2; white - Wnt4 (assay MGI:7567407); green - cytokeratin.
Structure Level Pattern Image Note
TS24: cap mesenchyme Present Regionally restricted 8h Cap mesenchyme was depleted in some heterozygotes.
Specimen 8i: embryonic day 16.5; Aclytm1.1Welk/Aclytm1.1Welk, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Six2; white - Wnt4 (assay MGI:7567407); green - cytokeratin.
Structure Level Pattern Image Note
TS24: cap mesenchyme Weak 8i Cap mesenchyme was depleted.
Specimen 8j: embryonic day 14.5; Aclytm1.1Welk/Acly+ (more )
Note: Triple labeled: red - Six2; white - Wnt4 (assay MGI:7567407); green - cytokeratin.
Structure Level Pattern Image Note
TS22: cap mesenchyme Present 8j
Specimen 8k: embryonic day 14.5; Aclytm1.1Welk/Acly+, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Six2; white - Wnt4 (assay MGI:7567407); green - cytokeratin.
Structure Level Pattern Image Note
TS22: cap mesenchyme Present Regionally restricted 8k Cap mesenchyme was depleted in some heterozygotes.
Specimen 8l: embryonic day 14.5; Aclytm1.1Welk/Aclytm1.1Welk, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: red - Six2; white - Wnt4 (assay MGI:7567407); green - cytokeratin.
Structure Level Pattern Image Note
TS22: cap mesenchyme Weak 8l Cap mesenchyme was depleted.
Specimen 9a: postnatal day 0; Aclytm1.1Welk/Acly+ (more )
Note: Double labeled: red - Six2; green - DBA.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present 9a Expression in cap mesenchyme forming a crescent around ureteric bud.
Specimen 9b: postnatal day 0; Aclytm1.1Welk/Acly+, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Double labeled: red - Six2; green - DBA.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present Regionally restricted 9b Expression affected in heterozygotes but to a lesser extent than for homozygotes.
Specimen 9c: postnatal day 0; Aclytm1.1Welk/Aclytm1.1Welk, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Double labeled: red - Six2; green - DBA.
Structure Level Pattern Image Note
TS27: cap mesenchyme Weak 9c Authors report a reduction of expressing cells compared to wild type.
Specimen 9e CTRL: postnatal day 0; Aclytm1.1Welk/Acly+ (more )
Note: Double labeled: red - Six2; green - DBA.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present 9e CTRL Expression in cap mesenchyme forming a crescent around ureteric bud.
Specimen 9e MUT: postnatal day 0; Aclytm1.1Welk/Aclytm1.1Welk, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Double labeled: red - Six2; green - DBA.
Structure Level Pattern Image Note
TS27: cap mesenchyme Weak 9e MUT Authors report a reduction of expressing cells compared to wild type.
Specimen S9b: postnatal day 0; Aclytm1.1Welk/Acly+ (more )
Note: Triple labeled: green - Six2; red - recombinase reporter; blue - Hoechst.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present S9b
Specimen S9d: postnatal day 0; Aclytm1.1Welk/Acly+, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: green - Six2; red - recombinase reporter; blue - Hoechst.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present Regionally restricted S9d Expression co-localized with recombinase expression
Specimen S9f: postnatal day 0; Aclytm1.1Welk/Aclytm1.1Welk, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: green - Six2; red - recombinase reporter; blue - Hoechst.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present Regionally restricted S9f Expression co-localized with recombinase expression
Specimen S9h: postnatal day 0; Aclytm1.1Welk/Aclytm1.1Welk, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Triple labeled: green - Six2; red - recombinase reporter; blue - Hoechst.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present Regionally restricted S9h Expression co-localized with recombinase expression
Specimen S10b/e: postnatal day 0; Aclytm1.1Welk/Acly+ (more )
Note: Triple labeled: green - Six2; red - Wnt4 (assay MGI:7567407); blue - Hoechst.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present S10e , S10b
Specimen S10g/j: postnatal day 0; Aclytm1.1Welk/Aclytm1.1Welk, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Multi-labeled: red - Six2; cyan - Wnt4 (assay MGI:7567407); green - DBA; blue - hoechst.
Structure Level Pattern Image Note
TS27: cap mesenchyme Weak S10g , S10j Authors report a reduction of expressing cells compared to wild type.
Specimen S10l/o: postnatal day 0; Aclytm1.1Welk/Aclytm1.1Welk, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Multi-labeled: red - Six2; cyan - Wnt4 (assay MGI:7567407); green - DBA; blue - hoechst.
Structure Level Pattern Image Note
TS27: cap mesenchyme Weak S10o , S10l Authors report a reduction of expressing cells compared to wild type.
Specimen S10q/t: postnatal day 0; Aclytm1.1Welk/Acly+ (more )
Note: Multi-labeled: red - Six2; cyan - Wnt4 (assay MGI:7567407); green - DBA; blue - hoechst.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present S10q , S10t
Specimen S10v/y: postnatal day 0; Aclytm1.1Welk/Aclytm1.1Welk, Tg(Six2-EGFP/cre)1Amc/0 (more )
Note: Conditional mutant. Multi-labeled: red - Six2; cyan - Wnt4 (assay MGI:7567407); green - DBA; blue - hoechst.
Structure Level Pattern Image Note
TS27: cap mesenchyme Weak S10y , S10v Authors report a reduction of expressing cells compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory