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Gene Expression Data
Assay Details
Assay
Reference: J:333559 Rupani DN, et al., Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling. Development. 2023 Jan 15;150(2):dev201097
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7539132
Gene symbol: Ins2
Gene name: insulin II
Antibody: anti-Insulin (IC1417A)
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen S3I Insulin Control: postnatal day 21; Adartm1Knk/?, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1a+/? (more )
Note: Double labeled: red - Ins2 and Ins1; green - Gcg (assay MGI:7539130). Control is either non-Cre-expressing OR Adar1 heterozygous litter mate.
Structure Cell Type Level Pattern Image Note
TS28: endocrine pancreas type B pancreatic cell Present S3I Control Insulin , S3I Control Merge , S3I Control Merge inset
Specimen S3I Insulin CYA (upper): postnatal day 21; Adartm1Knk/Adartm1Knk, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Gcg (assay MGI:7539130).
Structure Level Pattern Image Note
TS28: endocrine pancreas Present Regionally restricted S3I CYA Merge (upper) inset , S3I CYA Merge (upper) , S3I CYA Insulin (upper) Co-expression with glucagon in some cells.
Specimen S3I Insulin CYA (lower): postnatal day 21; Adartm1Knk/Adartm1Knk, Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Ptf1atm1.1(cre)Cvw/Ptf1a+ (more )
Note: Conditional mutant. Double labeled: red - Ins2 and Ins1; green - Gcg (assay MGI:7539130).
Structure Level Pattern Image Note
TS28: endocrine pancreas Present S3I CYA Merge (lower) inset , S3I CYA Insulin (lower) , S3I CYA Merge (lower)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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